3rr3

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[[Image:3rr3.png|left|200px]]
 
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==Structure of (R)-flurbiprofen bound to mCOX-2==
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The line below this paragraph, containing "STRUCTURE_3rr3", creates the "Structure Box" on the page.
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<StructureSection load='3rr3' size='340' side='right'caption='[[3rr3]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rr3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RR3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.842&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=FLR:(2R)-2-(3-FLUORO-4-PHENYL-PHENYL)PROPANOIC+ACID'>FLR</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_3rr3| PDB=3rr3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rr3 OCA], [https://pdbe.org/3rr3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rr3 RCSB], [https://www.ebi.ac.uk/pdbsum/3rr3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rr3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cyclooxygenase-2 (COX-2) catalyzes the oxygenation of arachidonic acid and the endocannabinoids 2-arachidonoylglycerol and arachidonoylethanolamide. Evaluation of a series of COX-2 inhibitors revealed that many weak competitive inhibitors of arachidonic acid oxygenation are potent inhibitors of endocannabinoid oxygenation. (R) enantiomers of ibuprofen, naproxen and flurbiprofen, which are considered to be inactive as COX-2 inhibitors, are potent 'substrate-selective inhibitors' of endocannabinoid oxygenation. Crystal structures of the COX-2-(R)-naproxen and COX-2-(R)-flurbiprofen complexes verified this unexpected binding and defined the orientation of the (R) enantiomers relative to (S) enantiomers. (R)-Profens selectively inhibited endocannabinoid oxygenation by lipopolysaccharide-stimulated dorsal root ganglion (DRG) cells. Substrate-selective inhibition provides new tools for investigating the role of COX-2 in endocannabinoid oxygenation and a possible explanation for the ability of (R)-profens to maintain endocannabinoid tone in models of neuropathic pain.
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===Structure of (R)-flurbiprofen bound to mCOX-2===
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(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2.,Duggan KC, Hermanson DJ, Musee J, Prusakiewicz JJ, Scheib JL, Carter BD, Banerjee S, Oates JA, Marnett LJ Nat Chem Biol. 2011 Nov;7(11):803-9. PMID:22053353<ref>PMID:22053353</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3rr3" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22053353 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22053353}}
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==About this Structure==
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[[3rr3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RR3 OCA].
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==See Also==
==See Also==
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*[[Cyclooxygenase]]
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*[[Cyclooxygenase 3D structures|Cyclooxygenase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022053353</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Prostaglandin-endoperoxide synthase]]
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[[Category: Banerjee S]]
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[[Category: Banerjee, S.]]
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[[Category: Carter BD]]
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[[Category: Carter, B D.]]
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[[Category: Duggan KC]]
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[[Category: Duggan, K C.]]
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[[Category: Hermanson DJ]]
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[[Category: Hermanson, D J.]]
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[[Category: Marnett LJ]]
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[[Category: Marnett, L J.]]
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[[Category: Musee J]]
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[[Category: Musee, J.]]
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[[Category: Oates JA]]
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[[Category: Oates, J A.]]
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[[Category: Prusakiewicz JJ]]
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[[Category: Prusakiewicz, J J.]]
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[[Category: Scheib J]]
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[[Category: Scheib, J.]]
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[[Category: Flurbiprofen]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Current revision

Structure of (R)-flurbiprofen bound to mCOX-2

PDB ID 3rr3

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