3csl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3csl" [edit=sysop:move=sysop])
Current revision (05:44, 17 October 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3csl.png|left|200px]]
 
-
<!--
+
==Structure of the Serratia marcescens hemophore receptor HasR in complex with its hemophore HasA and heme==
-
The line below this paragraph, containing "STRUCTURE_3csl", creates the "Structure Box" on the page.
+
<StructureSection load='3csl' size='340' side='right'caption='[[3csl]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3csl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CSL FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-
{{STRUCTURE_3csl| PDB=3csl | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3csl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csl OCA], [https://pdbe.org/3csl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3csl RCSB], [https://www.ebi.ac.uk/pdbsum/3csl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3csl ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q79AD2_SERMA Q79AD2_SERMA]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/3csl_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3csl ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Gram-negative bacteria use specific heme uptake systems, relying on outer membrane receptors and excreted heme-binding proteins (hemophores) to scavenge and actively transport heme. To unravel the unknown molecular details involved, we present 3 structures of the Serratia marcescens receptor HasR in complex with its hemophore HasA. The transfer of heme over a distance of 9 A from its high-affinity site in HasA into a site of lower affinity in HasR is coupled with the exergonic complex formation of the 2 proteins. Upon docking to the receptor, 1 of the 2 axial heme coordinations of the hemophore is initially broken, but the position and orientation of the heme is preserved. Subsequently, steric displacement of heme by a receptor residue ruptures the other axial coordination, leading to heme transfer into the receptor.
-
===Structure of the Serratia marcescens hemophore receptor HasR in complex with its hemophore HasA and heme===
+
Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex.,Krieg S, Huche F, Diederichs K, Izadi-Pruneyre N, Lecroisey A, Wandersman C, Delepelaire P, Welte W Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1045-50. Epub 2009 Jan 14. PMID:19144921<ref>PMID:19144921</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_19144921}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3csl" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 19144921 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_19144921}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[3csl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSL OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:019144921</ref><references group="xtra"/>
+
[[Category: Serratia marcescens]]
[[Category: Serratia marcescens]]
-
[[Category: Diederichs, K.]]
+
[[Category: Diederichs K]]
-
[[Category: Krieg, S.]]
+
[[Category: Krieg S]]
-
[[Category: Beta-barrel]]
+
-
[[Category: Heme]]
+
-
[[Category: Hemophore receptor]]
+
-
[[Category: Iron]]
+
-
[[Category: Membrane protein-heme binding protein complex]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Outer membrane protein]]
+
-
[[Category: Secreted]]
+
-
[[Category: Tonb box]]
+

Current revision

Structure of the Serratia marcescens hemophore receptor HasR in complex with its hemophore HasA and heme

PDB ID 3csl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3csl"
Personal tools