3kam

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[[Image:3kam.png|left|200px]]
 
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==Hen Egg White Lysozyme Derivatized with rhenium(I) diaquatricarbonyl cation==
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The line below this paragraph, containing "STRUCTURE_3kam", creates the "Structure Box" on the page.
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<StructureSection load='3kam' size='340' side='right'caption='[[3kam]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KAM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RE:RHENIUM'>RE</scene></td></tr>
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{{STRUCTURE_3kam| PDB=3kam | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kam OCA], [https://pdbe.org/3kam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kam RCSB], [https://www.ebi.ac.uk/pdbsum/3kam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kam ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/3kam_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kam ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The reaction of Re(CO)(3)(H(2)O)(3)(+) with hen egg lysozyme in aqueous solution results in a single covalent adduct; single crystal X-ray diffraction shows that the rhenium tricarbonyl cation binds to His15 in two significantly populated rotamer conformations.
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===Hen Egg White Lysozyme Derivatized with rhenium(I) diaquatricarbonyl cation===
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Specific derivatization of lysozyme in aqueous solution with Re(CO)3(H2O)3(+).,Binkley SL, Ziegler CJ, Herrick RS, Rowlett RS Chem Commun (Camb). 2010 Feb 28;46(8):1203-5. Epub 2010 Jan 9. PMID:20449250<ref>PMID:20449250</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20449250}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3kam" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20449250 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20449250}}
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==About this Structure==
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[[3kam]] is a 1 chain structure of [[Hen Egg-White (HEW) Lysozyme]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KAM OCA].
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==See Also==
==See Also==
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*[[Hen Egg-White (HEW) Lysozyme]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020449250</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Rowlett, R S.]]
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[[Category: Rowlett RS]]
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[[Category: Allergen]]
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[[Category: Antimicrobial]]
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[[Category: Bacteriolytic enzyme]]
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[[Category: Disulfide bond]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Lysozyme]]
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[[Category: Rhenium tricarbonyl]]
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Current revision

Hen Egg White Lysozyme Derivatized with rhenium(I) diaquatricarbonyl cation

PDB ID 3kam

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