4e02

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'''Unreleased structure'''
 
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The entry 4e02 is ON HOLD until Paper Publication
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==Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(S)-2-chloro-3-phenylpropanoic acid complex with AMPPNP==
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<StructureSection load='4e02' size='340' side='right'caption='[[4e02]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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Authors: Tso, S.C., Chuang, J.L., Gui, W.J., Wynn, R.M., Li, J., Chuang, D.T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4e02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E02 FirstGlance]. <br>
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Description: Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(S)-2-chloro-3-phenylpropanoic acid complex with AMPPNP
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1547&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=WJ1:(S)-2-CHLORO-3-PHENYLPROPANOIC+ACID'>WJ1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e02 OCA], [https://pdbe.org/4e02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e02 RCSB], [https://www.ebi.ac.uk/pdbsum/4e02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e02 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Chuang DT]]
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[[Category: Chuang JL]]
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[[Category: Gui WJ]]
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[[Category: Li J]]
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[[Category: Tso SC]]
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[[Category: Wynn RM]]

Current revision

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(S)-2-chloro-3-phenylpropanoic acid complex with AMPPNP

PDB ID 4e02

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