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4e28
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human thymidylate synthase in inactive conformation with a novel non-peptidic inhibitor== | |
| + | <StructureSection load='4e28' size='340' side='right'caption='[[4e28]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4e28]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E28 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.302Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0MZ:2-{(2Z,5S)-4-HYDROXY-2-[(2E)-(2-HYDROXYBENZYLIDENE)HYDRAZINYLIDENE]-2,5-DIHYDRO-1,3-THIAZOL-5-YL}-N-[3-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE'>0MZ</scene>, <scene name='pdbligand=9MZ:2-{(5S)-2-[(2E)-2-(2-HYDROXYBENZYLIDENE)HYDRAZINYL]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-5-YL}-N-[3-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE'>9MZ</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e28 OCA], [https://pdbe.org/4e28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e28 RCSB], [https://www.ebi.ac.uk/pdbsum/4e28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e28 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Costi MP]] | ||
| + | [[Category: Finer-Moore J]] | ||
| + | [[Category: Stroud RM]] | ||
| + | [[Category: Tochowicz A]] | ||
Current revision
Structure of human thymidylate synthase in inactive conformation with a novel non-peptidic inhibitor
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