4e4n
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4e4n is ON HOLD Authors: Eigenbrot, C. Description: kinase/inhibitor) |
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| - | '''Unreleased structure''' | ||
| - | + | ==JAK1 kinase (JH1 domain) in complex with compound 49== | |
| + | <StructureSection load='4e4n' size='340' side='right'caption='[[4e4n]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4e4n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E4N FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0NL:TERT-BUTYL+[(1R,3R)-3-(IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL)CYCLOPENTYL]CARBAMATE'>0NL</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e4n OCA], [https://pdbe.org/4e4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e4n RCSB], [https://www.ebi.ac.uk/pdbsum/4e4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e4n ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. | ||
| - | + | ==See Also== | |
| - | + | *[[Janus kinase 3D structures|Janus kinase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Eigenbrot C]] | ||
Current revision
JAK1 kinase (JH1 domain) in complex with compound 49
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