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4d8n

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[[Image:4d8n.jpg|left|200px]]
 
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==Human Kallikrein 6 Inhibitors with a para-Amidobenzylanmine P1 Group Carry a High Binding Efficiency==
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The line below this paragraph, containing "STRUCTURE_4d8n", creates the "Structure Box" on the page.
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<StructureSection load='4d8n' size='340' side='right'caption='[[4d8n]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4d8n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D8N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HM:2-{[4-(AMINOMETHYL)PHENYL]CARBAMOYL}-1-[(1-BENZYL-1H-IMIDAZOL-2-YL)METHYL]-3-HYDROXYPYRIDINIUM'>0HM</scene></td></tr>
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{{STRUCTURE_4d8n| PDB=4d8n | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d8n OCA], [https://pdbe.org/4d8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d8n RCSB], [https://www.ebi.ac.uk/pdbsum/4d8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d8n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KLK6_HUMAN KLK6_HUMAN] Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<ref>PMID:12878203</ref> <ref>PMID:12928483</ref> <ref>PMID:15557757</ref> <ref>PMID:16987227</ref> <ref>PMID:16321973</ref> <ref>PMID:11983703</ref>
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===Human Kallikrein 6 Inhibitors with a para-Amidobenzylanmine P1 Group Carry a High Binding Efficiency===
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==See Also==
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*[[Kallikrein 3D structures|Kallikrein 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22386244}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22386244 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22386244}}
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==About this Structure==
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[[4d8n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D8N OCA].
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==Reference==
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<ref group="xtra">PMID:022386244</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, X.]]
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[[Category: Large Structures]]
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[[Category: Wang, R.]]
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[[Category: Chen X]]
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[[Category: Xia, T.]]
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[[Category: Wang R]]
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[[Category: Amidinothiophene]]
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[[Category: Xia T]]
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[[Category: Hk6]]
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[[Category: Human kallikrein 6]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protein-ligand complex]]
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[[Category: Serine protease]]
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Current revision

Human Kallikrein 6 Inhibitors with a para-Amidobenzylanmine P1 Group Carry a High Binding Efficiency

PDB ID 4d8n

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