3sgp

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[[Image:3sgp.jpg|left|200px]]
 
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==Amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L==
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The line below this paragraph, containing "STRUCTURE_3sgp", creates the "Structure Box" on the page.
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<StructureSection load='3sgp' size='340' side='right'caption='[[3sgp]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sgp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SGP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4016&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
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{{STRUCTURE_3sgp| PDB=3sgp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgp OCA], [https://pdbe.org/3sgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sgp RCSB], [https://www.ebi.ac.uk/pdbsum/3sgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgp ProSAT]</span></td></tr>
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</table>
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===Amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L===
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== Disease ==
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[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
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The line below this paragraph, {{ABSTRACT_PUBMED_22403391}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22403391 is the PubMed ID number.
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</StructureSection>
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[[Category: Homo sapiens]]
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{{ABSTRACT_PUBMED_22403391}}
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[[Category: Large Structures]]
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[[Category: Cascio D]]
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==About this Structure==
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[[Category: Eisenberg D]]
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[[3sgp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGP OCA].
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[[Category: Laganowsky A]]
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[[Category: Sawaya MR]]
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==Reference==
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<ref group="xtra">PMID:022403391</ref><references group="xtra"/>
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[[Category: Cascio, D.]]
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[[Category: Eisenberg, D.]]
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[[Category: Laganowsky, A.]]
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[[Category: Sawaya, M R.]]
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[[Category: Amyloid]]
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[[Category: Amyloid oligomer]]
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[[Category: Beta cylindrin]]
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[[Category: Protein fibril]]
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Current revision

Amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L

PDB ID 3sgp

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OCA

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