3ur3

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[[Image:3ur3.jpg|left|200px]]
 
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==Structure of the Cmr2 subunit of the CRISPR RNA silencing complex==
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The line below this paragraph, containing "STRUCTURE_3ur3", creates the "Structure Box" on the page.
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<StructureSection load='3ur3' size='340' side='right'caption='[[3ur3]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ur3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UR3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.405&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3ur3| PDB=3ur3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ur3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ur3 OCA], [https://pdbe.org/3ur3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ur3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ur3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ur3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CMR2_PYRFU CMR2_PYRFU] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), formerly called psiRNA (prokaryotic silencing) in this organism. Part of the Cmr ribonucleoprotein complex which has divalent cation-dependent endoribonuclease activity specific for ssRNA complementary to the crRNA, generating 5' hydroxy- and 3' phosphate or 2'-3' cyclic phosphate termini. It is not known which subunit has endoribonuclease activity. Cmr complex does not cleave ssDNA complementary to the crRNA. Cleavage of invading RNA is guided by the crRNA; substrate cleavage occurs a fixed distance (14 nt) from the 3' end of the crRNA. In vitro reconstitution shows Cmr1-2 and Cmr5 are not necessary for cleavage. Probably not the subunit that cleaves pre-crRNA, as mutation of numerous metal-binding residues have no effect on cleavage by assembled complex.<ref>PMID:19945378</ref>
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===Structure of the Cmr2 subunit of the CRISPR RNA silencing complex===
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==See Also==
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22405013 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_22405013}}
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[[Category: Pyrococcus furiosus DSM 3638]]
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[[Category: Cocozaki AI]]
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==About this Structure==
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[[Category: Hale CR]]
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[[3ur3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UR3 OCA].
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[[Category: Li H]]
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[[Category: Ramia NF]]
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==Reference==
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[[Category: Shao Y]]
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<ref group="xtra">PMID:022405013</ref><references group="xtra"/>
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[[Category: Terns MP]]
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[[Category: Pyrococcus furiosus]]
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[[Category: Terns RM]]
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[[Category: Cocozaki, A I.]]
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[[Category: Hale, C R.]]
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[[Category: Li, H.]]
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[[Category: Ramia, N F.]]
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[[Category: Shao, Y.]]
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[[Category: Terns, M P.]]
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[[Category: Terns, R M.]]
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[[Category: Cmr complex]]
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[[Category: Ferredoxin fold]]
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[[Category: Nucleotide-binding]]
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[[Category: Polymerase]]
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[[Category: Unknown function]]
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Current revision

Structure of the Cmr2 subunit of the CRISPR RNA silencing complex

PDB ID 3ur3

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