4dym

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[[Image:4dym.jpg|left|200px]]
 
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==Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135==
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The line below this paragraph, containing "STRUCTURE_4dym", creates the "Structure Box" on the page.
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<StructureSection load='4dym' size='340' side='right'caption='[[4dym]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dym]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DYM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IYZ:1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE'>IYZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_4dym| PDB=4dym | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dym OCA], [https://pdbe.org/4dym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dym RCSB], [https://www.ebi.ac.uk/pdbsum/4dym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dym ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135===
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== Disease ==
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[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] Fibrodysplasia ossificans progressiva. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:[https://omim.org/entry/135100 135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.<ref>PMID:16642017</ref> <ref>PMID:19085907</ref> <ref>PMID:19330033</ref>
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
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[[4dym]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DYM OCA].
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Receptor protein serine/threonine kinase]]
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[[Category: Large Structures]]
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[[Category: Alfano, I.]]
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[[Category: Alfano I]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Bullock, A.]]
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[[Category: Bullock A]]
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[[Category: Canning, P.]]
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[[Category: Canning P]]
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[[Category: Chaikuad, A.]]
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[[Category: Chaikuad A]]
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[[Category: Cooper, C.]]
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[[Category: Cooper C]]
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[[Category: Daga, N.]]
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[[Category: Daga N]]
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[[Category: Delft, F von.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Fedorov O]]
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[[Category: Fedorov, O.]]
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[[Category: Filippakopoulos P]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Krojer T]]
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[[Category: Krojer, T.]]
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[[Category: Mahajan P]]
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[[Category: Mahajan, P.]]
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[[Category: Muniz JRC]]
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[[Category: Muniz, J R.C.]]
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[[Category: Petrie K]]
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[[Category: Petrie, K.]]
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[[Category: Sanvitale C]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Weigelt J]]
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[[Category: Sanvitale, C.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: Protein kinase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135

PDB ID 4dym

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