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Haloperoxidase

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{{STRUCTURE_2civ| PDB=2civ | SIZE=400| SCENE= |right|CAPTION=Heme-containing glycosylated chloroperoxidase complex with Br- ion, [[2civ]] }}
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<StructureSection load='1qi9' size='400' side='right' scene='48/486480/Cv/1' caption='Bromoperoxidase complex with VO4 and I- (purple) ions, [[1qi9]]'>
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<!--
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== Function ==
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Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
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'''Haloperoxidases''' catalyze the oxidation of halides by hydrogen peroxide while adding a halide to hydrocarbons. They are classified as '''chloroperoxldase''' (CPO), '''bromoperoxidase''' (BPO) and '''iodoperoxidase''' (IPO) according to the halide which they oxidize. CPO is heme-containing, vanadium-containing or metal-free. BPO from marine algae is vanadium-containing<ref>PMID:19363038</ref>.
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Or use the four-green-boxes-button to insert scrollable text adjacent
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to a Jmol applet. Check out the other buttons as well!
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-->
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'''Haloperoxidases''' catalyze the oxidation of halides by hydrogen peroxide while adding a halide to hydrocarbons. They are classified as '''chloroperoxldase''' (CPO), '''bromoperoxidase''' (BPO) and '''iodoperoxidase''' (IPO) according to the halide which they oxidize. CPO is heme-, vanadium-containing or metal-free. BPO from marine algae is vanadium-containing.
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'''Vanadium-containing chloroperoxidase'''
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== Structural highlights ==
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The <scene name='48/486480/Cv/5'>vanadate ion shows a trigonal bipyramidal coordination</scene>. The iodine atoms are coordinated to tyrosine residues: <scene name='48/486480/Cv/6'>first coordination site</scene> and <scene name='48/486480/Cv/7'>second coordination site</scene> <ref>PMID:10543953</ref>. Water molecules shown as red spheres.
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</StructureSection>
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==3D structures of haloperoxidase==
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[[1vnc]], [[1vni]], [[1idq]], [[1idu]] – CiCPO – ''Curvularia inaequalis''<br />
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[1vne]], [[1vnf]], [[1vng]], [[1vnh]] – CiCPO (mutant)<br />
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1vns]] – CiCPO no vanadium
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'''Heme-containing chloroperoxidase'''
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*Vanadium-dependent chloroperoxidase
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[[1cpo]], [[2cpo]] – LfCPO – ''Leptoxyphium fumago''<br />
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**[[1vnc]], [[1vni]], [[1idq]], [[1idu]] – CiCPO + VO4 – ''Curvularia inaequalis''<br />
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[[2civ]] – LfCPO + Br<br />
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**[[1vne]], [[1vnf]], [[1vng]], [[1vnh]] – CiCPO (mutant) + VO4<br />
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[[2ciw]] – LfCPO + I<br />
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**[[1vns]], [[3bb0]] – CiCPO <br />
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[[2cix]] – LfCPO + cyclopentane-dione + Br<br />
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**[[3w35]] – StCPO – ''Streptomyces''<br />
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[[2ciy]] – LfCPO + CN + DMSO + Br<br />
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**[[3w36]] – StCPO + VO4<br />
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[[2ciz]] – LfCPO + acetate + Br<br />
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**[[5lpc]] – CPO – ''Acaryochloris marina''<br />
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[[2cj0]] – LfCPO + nitrate<br />
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[[2cj1]], [[2cj2]] – LfCPO + formate<br />
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[[2j5m]] – LfCPO + H2O2
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'''Metal-free chloroperoxidase'''
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*Heme-containing chloroperoxidase
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[[1a7u]] - SaCPO T – ''Streptomyces aureofaciens''<br />
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**[[1cpo]], [[2cpo]] – LfCPO – ''Leptoxyphium fumago''<br />
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[[1a8s]] – PfCPO F + propanoic acid – ''Pseudomonas fluorescens''<br />
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**[[2civ]], [[2j18]], [[2j19]] – LfCPO + Br<br />
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[[1a8u]] – PfCPO T + benzoic acid<br />
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**[[2ciw]] – LfCPO + I<br />
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[[1a88]] - CPO L – ''Streptomyces lividans''
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**[[2cix]] – LfCPO + cyclopentane-dione + Br<br />
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**[[2ciy]] – LfCPO + CN + DMSO + Br<br />
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**[[2ciz]] – LfCPO + acetate + Br<br />
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**[[2cj0]] – LfCPO + nitrate<br />
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**[[2cj1]], [[2cj2]] – LfCPO + formate<br />
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**[[2j5m]] – LfCPO + H2O2
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'''Metal-free bromoperoxidase'''
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*Metal-free chloroperoxidase
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[[1a8q]] – SaBPO A1<br />
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**[[1a7u]] - SaCPO T – ''Streptomyces aureofaciens''<br />
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[[1bro]] - SaBPO A2<br />
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**[[1a8s]] – PfCPO F + propanoic acid – ''Pseudomonas fluorescens''<br />
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[[1brt]] – SaBPO A2 (mutant)<br />
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**[[1a8u]] – PfCPO T + benzoic acid<br />
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[[3fob]] – BPO – ''Bacillus anthracis''
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**[[1a88]] - CPO L – ''Streptomyces lividans''<br />
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**[[4dgq]] – CPO – ''Burkholderia cenocepacia''<br />
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'''Vanadium-containing bromoperoxidase'''
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*Metal-free bromoperoxidase
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[[1qi9]] – BPO + I – ''Ascophyllum nodosum''<br />
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**[[1a8q]] – SaBPO A1<br />
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[[1up8]] – BPO no vanadium – ''Corallina pilulifera''
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**[[1bro]] - SaBPO A2<br />
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**[[1brt]], [[4iq4]], [[4itv]], [[4ivj]], [[4qes]], [[4qf0]], [[4qff]] – SaBPO A2 (mutant)<br />
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**[[3fob]] – BPO – ''Bacillus anthracis''
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*Vanadium-containing bromoperoxidase
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**[[1qi9]] – AnBPO + I + VO4 – ''Ascophyllum nodosum''<br />
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**[[5aa6]] – AnBPO-2 + VO4<br />
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**[[1up8]], [[1qhb]], [[7qyy]] – CpBPO – ''Corallina pilulifera''<br />
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**[[7qvw]] – CpBPO (mutant) <br />
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**[[7qwi]] – CpBPO + VO4<br />
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**[[7qw3]] – CpBPO (mutant) + Br<br />
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*Vanadium-containing iodoperoxidase
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**[[4cit]], [[4usz]] – IPO + VO4 – ''Zobellia galactanivorans''<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Bromoperoxidase complex with VO4 and I- (purple) ions, 1qi9

Drag the structure with the mouse to rotate

3D structures of haloperoxidase

Updated on 27-April-2023

References

  1. ↑ Winter JM, Moore BS. Exploring the chemistry and biology of vanadium-dependent haloperoxidases. J Biol Chem. 2009 Jul 10;284(28):18577-81. doi: 10.1074/jbc.R109.001602. Epub, 2009 Apr 10. PMID:19363038 doi:http://dx.doi.org/10.1074/jbc.R109.001602
  2. ↑ Weyand M, Hecht H, Kiess M, Liaud M, Vilter H, Schomburg D. X-ray structure determination of a vanadium-dependent haloperoxidase from Ascophyllum nodosum at 2.0 A resolution. J Mol Biol. 1999 Oct 29;293(3):595-611. PMID:10543953 doi:10.1006/jmbi.1999.3179

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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