3pb3

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[[Image:3pb3.png|left|200px]]
 
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==Structure of an Antibiotic Related Methyltransferase==
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The line below this paragraph, containing "STRUCTURE_3pb3", creates the "Structure Box" on the page.
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<StructureSection load='3pb3' size='340' side='right'caption='[[3pb3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pb3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The February 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Aminoglycoside Antibiotics'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_2 10.2210/rcsb_pdb/mom_2012_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PB3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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{{STRUCTURE_3pb3| PDB=3pb3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pb3 OCA], [https://pdbe.org/3pb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pb3 RCSB], [https://www.ebi.ac.uk/pdbsum/3pb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pb3 ProSAT]</span></td></tr>
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</table>
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===Structure of an Antibiotic Related Methyltransferase===
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== Function ==
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[https://www.uniprot.org/uniprot/NPMA_ECOLX NPMA_ECOLX] Specifically methylates the N(1) position of adenine 1408 in 16S rRNA. Confers resistance to various aminoglycosides, including kanamycin, neomycin, apramycin, ribostamycin and gentamicin. Methylates only fully assembled 30S subunits.<ref>PMID:17875999</ref> <ref>PMID:20667473</ref> <ref>PMID:21062819</ref>
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21062819 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21062819}}
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==About this Structure==
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[[3pb3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The February 2012 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Aminoglycoside Antibiotics'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2012_2 10.2210/rcsb_pdb/mom_2012_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PB3 OCA].
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==Reference==
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<ref group="xtra">PMID:021062819</ref><references group="xtra"/>
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[[Category: Aminoglycoside Antibiotics]]
[[Category: Aminoglycoside Antibiotics]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Husain, N.]]
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[[Category: Husain N]]
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[[Category: Sivaraman, J.]]
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[[Category: Sivaraman J]]
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[[Category: Antibiotic resistance]]
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[[Category: Methyltransferase]]
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[[Category: Npma]]
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[[Category: Transferase]]
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Current revision

Structure of an Antibiotic Related Methyltransferase

PDB ID 3pb3

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