2lo0

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[[Image:2lo0.png|left|200px]]
 
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==Solution structure of the Get5 carboxyl domain from A. fumigatus==
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The line below this paragraph, containing "STRUCTURE_2lo0", creates the "Structure Box" on the page.
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<StructureSection load='2lo0' size='340' side='right'caption='[[2lo0]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lo0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus_Af293 Aspergillus fumigatus Af293]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LO0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lo0 OCA], [https://pdbe.org/2lo0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lo0 RCSB], [https://www.ebi.ac.uk/pdbsum/2lo0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lo0 ProSAT]</span></td></tr>
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{{STRUCTURE_2lo0| PDB=2lo0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q4WE50_ASPFU Q4WE50_ASPFU]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tail-anchored trans-membrane proteins are targeted to membranes post-translationally. The proteins Get4 and Get5 form an obligate complex that catalyzes the transfer of tail-anchored proteins destined to the endoplasmic reticulum from Sgt2 to the cytosolic targeting factor Get3. Get5 forms a homodimer mediated by its carboxyl domain. We show here that a conserved motif exists within the carboxyl domain. A high resolution crystal structure and solution NMR structures of this motif reveal a novel and stable helical dimerization domain. We additionally determined a solution NMR structure of a divergent fungal homolog, and comparison of these structures allows annotation of specific stabilizing interactions. Using solution x-ray scattering and the structures of all folded domains, we present a model of the full-length Get4/Get5 complex.
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===Solution structure of the Get5 carboxyl domain from A. fumigatus===
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Get5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 Complex.,Chartron JW, Vandervelde DG, Rao M, Clemons WM Jr J Biol Chem. 2012 Mar 9;287(11):8310-7. Epub 2012 Jan 17. PMID:22262836<ref>PMID:22262836</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22262836}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2lo0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22262836 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22262836}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Aspergillus fumigatus Af293]]
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[[2lo0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO0 OCA].
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[[Category: Large Structures]]
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[[Category: Chartron JW]]
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==Reference==
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[[Category: Clemons Jr WM]]
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<ref group="xtra">PMID:022262836</ref><references group="xtra"/>
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[[Category: Rao M]]
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[[Category: Aspergillus fumigatus]]
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[[Category: Vandervelde DG]]
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[[Category: Chartron, J W.]]
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[[Category: Clemons, W M.]]
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[[Category: Rao, M.]]
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[[Category: Vandervelde, D G.]]
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[[Category: Dimerization]]
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[[Category: Homodimerization]]
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[[Category: Protein binding]]
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Current revision

Solution structure of the Get5 carboxyl domain from A. fumigatus

PDB ID 2lo0

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OCA

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