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2wp2

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[[Image:2wp2.png|left|200px]]
 
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==Structure of Brdt bromodomain BD1 bound to a diacetylated histone H4 peptide.==
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The line below this paragraph, containing "STRUCTURE_2wp2", creates the "Structure Box" on the page.
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<StructureSection load='2wp2' size='340' side='right'caption='[[2wp2]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wp2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WP2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
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{{STRUCTURE_2wp2| PDB=2wp2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wp2 OCA], [https://pdbe.org/2wp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wp2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wp2 ProSAT]</span></td></tr>
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</table>
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===Structure of Brdt bromodomain BD1 bound to a diacetylated histone H4 peptide.===
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== Function ==
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[https://www.uniprot.org/uniprot/BRDT_MOUSE BRDT_MOUSE] Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.<ref>PMID:12861021</ref> <ref>PMID:22901802</ref> <ref>PMID:22922464</ref> <ref>PMID:22570411</ref> <ref>PMID:19794495</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_19794495}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19794495 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wp/2wp2_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19794495}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[2wp2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WP2 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wp2 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:019794495</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Curtet, S.]]
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[[Category: Curtet S]]
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[[Category: Gaucher, J.]]
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[[Category: Gaucher J]]
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[[Category: Govin, J.]]
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[[Category: Govin J]]
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[[Category: Hart, D J.]]
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[[Category: Hart DJ]]
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[[Category: Khochbin, S.]]
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[[Category: Khochbin S]]
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[[Category: Krijgsveld, J.]]
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[[Category: Krijgsveld J]]
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[[Category: Moriniere, J.]]
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[[Category: Moriniere J]]
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[[Category: Mueller, C W.]]
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[[Category: Mueller CW]]
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[[Category: Petosa, C.]]
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[[Category: Petosa C]]
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[[Category: Rousseaux, S.]]
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[[Category: Rousseaux S]]
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[[Category: Sadoul, K.]]
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[[Category: Sadoul K]]
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[[Category: Soler-Lopez, M.]]
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[[Category: Soler-Lopez M]]
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[[Category: Steuerwald, U.]]
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[[Category: Steuerwald U]]
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[[Category: Vitte, A L.]]
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[[Category: Vitte A-L]]
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[[Category: Acetyllysine]]
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[[Category: Brdt]]
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[[Category: Chromosomal protein]]
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[[Category: Nucleosome]]
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[[Category: Nucleus]]
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[[Category: Transcription regulation]]
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[[Category: Transcription-peptide complex]]
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Current revision

Structure of Brdt bromodomain BD1 bound to a diacetylated histone H4 peptide.

PDB ID 2wp2

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