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3k5t

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[[Image:3k5t.png|left|200px]]
 
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==Crystal structure of human diamine oxidase in space group C2221==
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The line below this paragraph, containing "STRUCTURE_3k5t", creates the "Structure Box" on the page.
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<StructureSection load='3k5t' size='340' side='right'caption='[[3k5t]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3k5t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K5T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TPQ:5-(2-CARBOXY-2-AMINOETHYL)-2-HYDROXY-1,4-BENZOQUINONE'>TPQ</scene></td></tr>
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{{STRUCTURE_3k5t| PDB=3k5t | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k5t OCA], [https://pdbe.org/3k5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k5t RCSB], [https://www.ebi.ac.uk/pdbsum/3k5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k5t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AOC1_HUMAN AOC1_HUMAN] Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/3k5t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k5t ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Copper amine oxidases (CAOs) are ubiquitous in nature and catalyse the oxidative deamination of primary amines to the corresponding aldehydes. Humans have three viable CAO genes (AOC1-3). AOC1 encodes human diamine oxidase (hDAO), which is the frontline enzyme for histamine metabolism. hDAO is unique among CAOs in that it has a distinct substrate preference for diamines. The structure of hDAO in space group P2(1)2(1)2(1) with two molecules in the asymmetric unit has recently been reported. Here, the structure of hDAO refined to 2.1 A resolution in space group C222(1) with one molecule in the asymmetric unit is reported.
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===Crystal structure of human diamine oxidase in space group C2221===
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A new crystal form of human diamine oxidase.,McGrath AP, Hilmer KM, Collyer CA, Dooley DM, Guss JM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Feb 1;66(Pt 2):137-42., Epub 2010 Jan 27. PMID:20124708<ref>PMID:20124708</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20124708}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3k5t" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20124708 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20124708}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3k5t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K5T OCA].
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==Reference==
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<ref group="xtra">PMID:020124708</ref><references group="xtra"/>
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[[Category: Diamine oxidase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Guss, J M.]]
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[[Category: Large Structures]]
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[[Category: McGrath, A P.]]
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[[Category: Guss JM]]
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[[Category: Cao]]
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[[Category: McGrath AP]]
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[[Category: Copper amine oxidase]]
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[[Category: Dao]]
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[[Category: Diamine oxidase]]
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[[Category: Glycoprotein]]
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[[Category: Heparin-binding]]
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[[Category: Human]]
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[[Category: Metal-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Secreted]]
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[[Category: Topaquinone]]
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[[Category: Tpq]]
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Current revision

Crystal structure of human diamine oxidase in space group C2221

PDB ID 3k5t

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