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3e4u

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[[Image:3e4u.png|left|200px]]
 
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==Crystal Structure of the Wild-Type Human BCL6 BTB/POZ Domain==
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The line below this paragraph, containing "STRUCTURE_3e4u", creates the "Structure Box" on the page.
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<StructureSection load='3e4u' size='340' side='right'caption='[[3e4u]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3e4u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E4U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e4u OCA], [https://pdbe.org/3e4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e4u RCSB], [https://www.ebi.ac.uk/pdbsum/3e4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e4u ProSAT]</span></td></tr>
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{{STRUCTURE_3e4u| PDB=3e4u | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
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== Function ==
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e4/3e4u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e4u ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Wild-Type Human BCL6 BTB/POZ Domain===
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19052359}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19052359 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19052359}}
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==About this Structure==
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[[3e4u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4U OCA].
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==Reference==
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<ref group="xtra">PMID:019052359</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Carr, S B.]]
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[[Category: Large Structures]]
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[[Category: Hadden, J M.]]
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[[Category: Carr SB]]
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[[Category: Rosbrook, G O.]]
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[[Category: Hadden JM]]
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[[Category: Stead, M A.]]
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[[Category: Rosbrook GO]]
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[[Category: Trinh, C H.]]
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[[Category: Stead MA]]
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[[Category: Wright, S C.]]
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[[Category: Trinh CH]]
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[[Category: Activator]]
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[[Category: Wright SC]]
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[[Category: Btb/poz protein interaction domain]]
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[[Category: Dna-binding]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Proto-oncogene]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc-finger]]
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Current revision

Crystal Structure of the Wild-Type Human BCL6 BTB/POZ Domain

PDB ID 3e4u

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