3zxs

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[[Image:3zxs.png|left|200px]]
 
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==Cryptochrome B from Rhodobacter sphaeroides==
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The line below this paragraph, containing "STRUCTURE_3zxs", creates the "Structure Box" on the page.
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<StructureSection load='3zxs' size='340' side='right'caption='[[3zxs]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3zxs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides_2.4.1 Cereibacter sphaeroides 2.4.1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLZ:1-DEOXY-1-(6,7-DIMETHYL-2,4-DIOXO-3,4-DIHYDROPTERIDIN-8(2H)-YL)-D-RIBITOL'>DLZ</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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{{STRUCTURE_3zxs| PDB=3zxs | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxs OCA], [https://pdbe.org/3zxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxs RCSB], [https://www.ebi.ac.uk/pdbsum/3zxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q3IXP1_CERS4 Q3IXP1_CERS4]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cryptochromes and photolyases are structurally related but have different biological functions in signalling and DNA repair. Proteobacteria and cyanobacteria harbour a new class of cryptochromes, called CryPro. We have solved the 2.7 A structure of one of its members, cryptochrome B from Rhodobacter sphaeroides, which is a regulator of photosynthesis gene expression. The structure reveals that, in addition to the photolyase-like fold, CryB contains two cofactors only conserved in the CryPro subfamily: 6,7-dimethyl-8-ribityl-lumazine in the antenna-binding domain and a [4Fe-4S] cluster within the catalytic domain. The latter closely resembles the iron-sulphur cluster harbouring the large primase subunit PriL, indicating that PriL is evolutionarily related to the CryPro class of cryptochromes.
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===Cryptochrome B from Rhodobacter sphaeroides===
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CryB from Rhodobacter sphaeroides: a unique class of cryptochromes with new cofactors.,Geisselbrecht Y, Fruhwirth S, Schroeder C, Pierik AJ, Klug G, Essen LO EMBO Rep. 2012 Jan 31. doi: 10.1038/embor.2012.2. PMID:22290493<ref>PMID:22290493</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zxs" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22290493}}, adds the Publication Abstract to the page
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*[[Cryptochrome 3D structures|Cryptochrome 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22290493 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22290493}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Cereibacter sphaeroides 2 4.1]]
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[[3zxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXS OCA].
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[[Category: Large Structures]]
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[[Category: Essen L-O]]
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==Reference==
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[[Category: Fruhwirth S]]
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<ref group="xtra">PMID:022290493</ref><references group="xtra"/>
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[[Category: Geisselbrecht Y]]
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[[Category: Rhodobacter sphaeroides]]
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[[Category: Klug G]]
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[[Category: Essen, L O.]]
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[[Category: Pierik AJ]]
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[[Category: Fruhwirth, S.]]
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[[Category: Geisselbrecht, Y.]]
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[[Category: Klug, G.]]
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[[Category: Pierik, A J.]]
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[[Category: Crypro]]
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[[Category: Iron-sulfur-cluster]]
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[[Category: Lumazine]]
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[[Category: Lyase]]
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Current revision

Cryptochrome B from Rhodobacter sphaeroides

PDB ID 3zxs

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