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3t94

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[[Image:3t94.png|left|200px]]
 
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==Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) II complexed with 5'-deoxy-5'-methylthioadenosine and sulfate==
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The line below this paragraph, containing "STRUCTURE_3t94", creates the "Structure Box" on the page.
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<StructureSection load='3t94' size='340' side='right'caption='[[3t94]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t94]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T94 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.452&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3t94| PDB=3t94 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t94 OCA], [https://pdbe.org/3t94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t94 RCSB], [https://www.ebi.ac.uk/pdbsum/3t94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t94 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTAP_SACS2 MTAP_SACS2] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.[HAMAP-Rule:MF_01963]<ref>PMID:15819883</ref>
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===Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) II complexed with 5'-deoxy-5'-methylthioadenosine and sulfate===
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==See Also==
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*[[5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures|5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22349226 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_22349226}}
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[[Category: Saccharolobus solfataricus]]
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[[Category: Ealick SE]]
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==About this Structure==
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[[Category: Zhang Y]]
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[[3t94]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T94 OCA].
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==Reference==
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<ref group="xtra">PMID:022349226</ref><ref group="xtra">PMID:016414070</ref><references group="xtra"/>
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[[Category: S-methyl-5'-thioadenosine phosphorylase]]
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[[Category: Sulfolobus solfataricus]]
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[[Category: Ealick, S E.]]
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[[Category: Zhang, Y.]]
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[[Category: Alpha/beta]]
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[[Category: Beta barrel]]
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[[Category: Nucleoside phosphorylase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) II complexed with 5'-deoxy-5'-methylthioadenosine and sulfate

PDB ID 3t94

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