2li5

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[[Image:2li5.png|left|200px]]
 
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==NMR structure of Atg8-Atg7C30 complex==
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The line below this paragraph, containing "STRUCTURE_2li5", creates the "Structure Box" on the page.
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<StructureSection load='2li5' size='340' side='right'caption='[[2li5]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2li5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LI5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2li5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2li5 OCA], [https://pdbe.org/2li5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2li5 RCSB], [https://www.ebi.ac.uk/pdbsum/2li5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2li5 ProSAT]</span></td></tr>
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{{STRUCTURE_2li5| PDB=2li5 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATG8_YEAST ATG8_YEAST] Involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes formation. With ATG4, may mediate the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton. Participates also in membrane fusion events that take place in the early secretory pathway.<ref>PMID:8224160</ref> <ref>PMID:7593182</ref> <ref>PMID:9649430</ref> <ref>PMID:10525546</ref> <ref>PMID:10681575</ref> <ref>PMID:10837468</ref> <ref>PMID:11038174</ref> <ref>PMID:11100732</ref> <ref>PMID:11149920</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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E1 enzymes activate ubiquitin-like proteins and transfer them to cognate E2 enzymes. Atg7, a noncanonical E1, activates two ubiquitin-like proteins, Atg8 and Atg12, and plays a crucial role in autophagy. Here, we report crystal structures of full-length Atg7 and its C-terminal domain bound to Atg8 and MgATP, as well as a solution structure of Atg8 bound to the extreme C-terminal domain (ECTD) of Atg7. The unique N-terminal domain (NTD) of Atg7 is responsible for Atg3 (E2) binding, whereas its C-terminal domain is comprised of a homodimeric adenylation domain (AD) and ECTD. The structural and biochemical data demonstrate that Atg8 is initially recognized by the C-terminal tail of ECTD and is then transferred to an AD, where the Atg8 C terminus is attacked by the catalytic cysteine to form a thioester bond. Atg8 is then transferred via a trans mechanism to the Atg3 bound to the NTD of the opposite protomer within a dimer.
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===NMR structure of Atg8-Atg7C30 complex===
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Structural basis of Atg8 activation by a homodimeric E1, Atg7.,Noda NN, Satoo K, Fujioka Y, Kumeta H, Ogura K, Nakatogawa H, Ohsumi Y, Inagaki F Mol Cell. 2011 Nov 4;44(3):462-75. PMID:22055191<ref>PMID:22055191</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2li5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Autophagy-related protein 3D structures|Autophagy-related protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22055191 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22055191}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2li5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LI5 OCA].
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Fujioka Y]]
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==Reference==
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[[Category: Inagaki F]]
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<ref group="xtra">PMID:022055191</ref><references group="xtra"/>
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[[Category: Kumeta H]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Nakatogawa H]]
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[[Category: Fujioka, Y.]]
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[[Category: Noda NN]]
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[[Category: Inagaki, F.]]
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[[Category: Ogura K]]
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[[Category: Kumeta, H.]]
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[[Category: Ohsumi Y]]
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[[Category: Nakatogawa, H.]]
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[[Category: Satoo K]]
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[[Category: Noda, N N.]]
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[[Category: Ogura, K.]]
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[[Category: Ohsumi, Y.]]
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[[Category: Satoo, K.]]
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[[Category: Atg8]]
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[[Category: Autophagy]]
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[[Category: Protein transport]]
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[[Category: Ubiquitin like]]
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Current revision

NMR structure of Atg8-Atg7C30 complex

PDB ID 2li5

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