3ik5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3ik5" [edit=sysop:move=sysop])
Current revision (10:05, 21 February 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3ik5.png|left|200px]]
 
-
<!--
+
==SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)==
-
The line below this paragraph, containing "STRUCTURE_3ik5", creates the "Structure Box" on the page.
+
<StructureSection load='3ik5' size='340' side='right'caption='[[3ik5]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3ik5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus_-_cpz Simian immunodeficiency virus - cpz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IK5 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ik5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik5 OCA], [https://pdbe.org/3ik5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ik5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ik5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik5 ProSAT]</span></td></tr>
-
{{STRUCTURE_3ik5| PDB=3ik5 | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NEF_SIVMA NEF_SIVMA] Seems to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Enhances virus infectivity and pathogenicity. Probably involved in viral immune evasion mechanisms (By similarity). In infected CD4(+) T-lymphocytes, down-regulates cell surface expression of CD4, CD28, CD3, and MHC-I or MHC-II molecules. Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/3ik5_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ik5 ConSurf].
 +
<div style="clear:both"></div>
-
===SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)===
+
==See Also==
-
 
+
*[[CD3 3D structures|CD3 3D structures]]
-
 
+
*[[Protein Nef 3D structures|Protein Nef 3D structures]]
-
<!--
+
__TOC__
-
The line below this paragraph, {{ABSTRACT_PUBMED_20124696}}, adds the Publication Abstract to the page
+
</StructureSection>
-
(as it appears on PubMed at http://www.pubmed.gov), where 20124696 is the PubMed ID number.
+
[[Category: Homo sapiens]]
-
-->
+
[[Category: Large Structures]]
-
{{ABSTRACT_PUBMED_20124696}}
+
[[Category: Simian immunodeficiency virus - cpz]]
-
 
+
[[Category: Kim WM]]
-
==About this Structure==
+
[[Category: Sigalov AB]]
-
[[3ik5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK5 OCA].
+
[[Category: Stern LJ]]
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:020124696</ref><references group="xtra"/>
+
-
[[Category: Simian immunodeficiency virus]]
+
-
[[Category: Kim, W M.]]
+
-
[[Category: Sigalov, A B.]]
+
-
[[Category: Stern, L J.]]
+
-
[[Category: Cell membrane]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Host-virus interaction]]
+
-
[[Category: Lipoprotein]]
+
-
[[Category: Membrane]]
+
-
[[Category: Myristate]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Protein-protein complex]]
+
-
[[Category: Receptor]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Viral immunoevasion]]
+
-
[[Category: Viral protein-antiviral protein complex]]
+
-
[[Category: Viral protein-signaling protein complex]]
+
-
[[Category: Virulence]]
+

Current revision

SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)

PDB ID 3ik5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ik5"
Personal tools