4a34

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[[Image:4a34.png|left|200px]]
 
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==Crystal structure of the fucose mutarotase in complex with L-fucose from Streptococcus pneumoniae==
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The line below this paragraph, containing "STRUCTURE_4a34", creates the "Structure Box" on the page.
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<StructureSection load='4a34' size='340' side='right'caption='[[4a34]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4a34]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A34 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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{{STRUCTURE_4a34| PDB=4a34 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a34 OCA], [https://pdbe.org/4a34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a34 RCSB], [https://www.ebi.ac.uk/pdbsum/4a34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a34 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0H2ZNZ5_STRP2 A0A0H2ZNZ5_STRP2]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Streptococcus pneumoniae relies on a variety of carbohydrate-utilization pathways for both colonization of its human host and full virulence during the development of invasive disease. One such pathway is the fucose-utilization pathway, a component of which is fucose mutarotase (SpFcsU), an enzyme that performs the interconversion between alpha-L-fucose and beta-L-fucose. This protein was crystallized and its three-dimensional structure was solved in complex with L-fucose. The structure shows a complex decameric quaternary structure with a high overall degree of structural identity to Escherichia coli FcsU (EcFcsU). Furthermore, the active-site architecture of SpFcsU is highly similar to that of EcFcsU. When considered in the context of the fucose-utilization pathway found in S. pneumoniae, SpFcsU appears to link the two halves of the pathway by enhancing the rate of conversion of the product of the final glycoside hydrolysis step, beta-fucose, into the substrate for the fucose isomerase, alpha-fucose.
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===Crystal structure of the fucose mutarotase in complex with L-fucose from Streptococcus pneumoniae===
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Structure of the fucose mutarotase from Streptococcus pneumoniae in complex with L-fucose.,Higgins MA, Boraston AB Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1524-30., Epub 2011 Nov 30. PMID:22139157<ref>PMID:22139157</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4a34" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22139157 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22139157}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4a34]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A34 OCA].
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[[Category: Streptococcus pneumoniae TIGR4]]
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[[Category: Boraston AB]]
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==Reference==
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[[Category: Higgins MA]]
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<ref group="xtra">PMID:022139157</ref><references group="xtra"/>
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[[Category: Streptococcus pneumoniae]]
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[[Category: Boraston, A B.]]
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[[Category: Higgins, M A.]]
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[[Category: Isomerase]]
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Current revision

Crystal structure of the fucose mutarotase in complex with L-fucose from Streptococcus pneumoniae

PDB ID 4a34

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