3ujl

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[[Image:3ujl.png|left|200px]]
 
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==Crystal structure of abscisic acid bound PYL2 in complex with type 2C protein phosphatase ABI2==
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The line below this paragraph, containing "STRUCTURE_3ujl", creates the "Structure Box" on the page.
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<StructureSection load='3ujl' size='340' side='right'caption='[[3ujl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ujl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UJL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A8S:(2Z,4E)-5-[(1S)-1-HYDROXY-2,6,6-TRIMETHYL-4-OXOCYCLOHEX-2-EN-1-YL]-3-METHYLPENTA-2,4-DIENOIC+ACID'>A8S</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3ujl| PDB=3ujl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ujl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ujl OCA], [https://pdbe.org/3ujl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ujl RCSB], [https://www.ebi.ac.uk/pdbsum/3ujl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ujl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Abscisic acid (ABA) is an essential hormone for plants to survive environmental stresses. At the center of the ABA signaling network is a subfamily of type 2C protein phosphatases (PP2Cs), which form exclusive interactions with ABA receptors and subfamily 2 Snfl-related kinase (SnRK2s). Here, we report a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors. In the complex, the kinase activation loop docks into the active site of PP2C, while the conserved ABA-sensing tryptophan of PP2C inserts into the kinase catalytic cleft, thus mimicking receptor-PP2C interactions. These structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites.
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===Crystal structure of abscisic acid bound PYL2 in complex with type 2C protein phosphatase ABI2===
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Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.,Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MH, Suino-Powell KM, He Y, Xu Y, Chalmers MJ, Brunzelle JS, Zhang H, Yang H, Jiang H, Li J, Yong EL, Cutler S, Zhu JK, Griffin PR, Melcher K, Xu HE Science. 2012 Jan 6;335(6064):85-8. Epub 2011 Nov 24. PMID:22116026<ref>PMID:22116026</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ujl" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22116026}}, adds the Publication Abstract to the page
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*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22116026 is the PubMed ID number.
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*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_22116026}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3ujl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJL OCA].
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==Reference==
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<ref group="xtra">PMID:022116026</ref><references group="xtra"/>
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[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Brunzelle, J S.]]
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[[Category: Brunzelle JS]]
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[[Category: He, Y.]]
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[[Category: He Y]]
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[[Category: Kovach, A.]]
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[[Category: Kovach A]]
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[[Category: Li, J.]]
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[[Category: Li J]]
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[[Category: Melcher, K.]]
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[[Category: Melcher K]]
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[[Category: Ng, L M.]]
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[[Category: Ng L-M]]
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[[Category: Soon, F F.]]
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[[Category: Soon F-F]]
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[[Category: Suino-Powell, K M.]]
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[[Category: Suino-Powell KM]]
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[[Category: Tan, M H.E.]]
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[[Category: Tan MHE]]
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[[Category: Xu, H E.]]
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[[Category: Xu HE]]
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[[Category: Xu, Y.]]
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[[Category: Xu Y]]
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[[Category: Zhou, X E.]]
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[[Category: Zhou XE]]
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[[Category: Aba signaling]]
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[[Category: Abi2]]
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[[Category: Abscisic receptor]]
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[[Category: Protein phosphatase 2c]]
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[[Category: Pyl2]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of abscisic acid bound PYL2 in complex with type 2C protein phosphatase ABI2

PDB ID 3ujl

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