3pmk

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[[Image:3pmk.png|left|200px]]
 
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==Crystal structure of the Vesicular Stomatitis Virus RNA free nucleoprotein/phosphoprotein complex==
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The line below this paragraph, containing "STRUCTURE_3pmk", creates the "Structure Box" on the page.
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<StructureSection load='3pmk' size='340' side='right'caption='[[3pmk]], [[Resolution|resolution]] 3.03&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pmk]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Recombinant_vesicular_stomatitis_Indiana_virus_rVSV-G/GFP Recombinant vesicular stomatitis Indiana virus rVSV-G/GFP]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PMK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.03&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pmk OCA], [https://pdbe.org/3pmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pmk RCSB], [https://www.ebi.ac.uk/pdbsum/3pmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pmk ProSAT]</span></td></tr>
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{{STRUCTURE_3pmk| PDB=3pmk | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B7UCZ2_9RHAB B7UCZ2_9RHAB]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Replication of non-segmented negative-strand RNA viruses requires the continuous supply of the nucleoprotein (N) in the form of a complex with the phosphoprotein (P). Here, we present the structural characterization of a soluble, heterodimeric complex between a variant of vesicular stomatitis virus N lacking its 21 N-terminal residues (N(Delta21)) and a peptide of 60 amino acids (P(60)) encompassing the molecular recognition element (MoRE) of P that binds RNA-free N (N(0)). The complex crystallized in a decameric circular form, which was solved at 3.0 A resolution, reveals how the MoRE folds upon binding to N and competes with RNA binding and N polymerization. Small-angle X-ray scattering experiment and NMR spectroscopy on the soluble complex confirms the binding of the MoRE and indicates that its flanking regions remain flexible in the complex. The structure of this complex also suggests a mechanism for the initiation of viral RNA synthesis.
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===Crystal structure of the Vesicular Stomatitis Virus RNA free nucleoprotein/phosphoprotein complex===
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Structure of the vesicular stomatitis virus N-P complex.,Leyrat C, Yabukarski F, Tarbouriech N, Ribeiro EA Jr, Jensen MR, Blackledge M, Ruigrok RW, Jamin M PLoS Pathog. 2011 Sep;7(9):e1002248. Epub 2011 Sep 22. PMID:21960769<ref>PMID:21960769</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3pmk" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21960769}}, adds the Publication Abstract to the page
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21960769 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21960769}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3pmk]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PMK OCA].
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[[Category: Recombinant vesicular stomatitis Indiana virus rVSV-G/GFP]]
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[[Category: Jamin M]]
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==Reference==
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[[Category: Leyrat C]]
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<ref group="xtra">PMID:021960769</ref><references group="xtra"/>
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[[Category: Ruigrok RWH]]
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[[Category: Viruses]]
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[[Category: Tarbouriech N]]
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[[Category: Jamin, M.]]
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[[Category: Yabukarski F]]
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[[Category: Leyrat, C.]]
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[[Category: Ruigrok, R W.H.]]
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[[Category: Tarbouriech, N.]]
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[[Category: Yabukarski, F.]]
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[[Category: Chaperone]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of the Vesicular Stomatitis Virus RNA free nucleoprotein/phosphoprotein complex

PDB ID 3pmk

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