3t95

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[[Image:3t95.png|left|200px]]
 
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==Crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2==
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The line below this paragraph, containing "STRUCTURE_3t95", creates the "Structure Box" on the page.
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<StructureSection load='3t95' size='340' side='right'caption='[[3t95]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t95]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_CO92 Yersinia pestis CO92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T95 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PAV:(2R,4S)-2-METHYL-2,3,3,4-TETRAHYDROXYTETRAHYDROFURAN'>PAV</scene></td></tr>
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{{STRUCTURE_3t95| PDB=3t95 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t95 OCA], [https://pdbe.org/3t95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t95 RCSB], [https://www.ebi.ac.uk/pdbsum/3t95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t95 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LSRB_YERPE LSRB_YERPE] Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2 (AI-2; space group P2(1)2(1)2(1), unit-cell parameters a = 40.61, b = 61.03, c = 125.23 A) has been solved by molecular replacement using the structure of LsrB from Salmonella typhimurium (PDB entry 1tjy) and refined to R = 0.180 (R(free) = 0.213) at 1.75 A resolution. The electron density for bound AI-2 and the stereochemistry of the AI-2-binding site are consistent with bound AI-2 adopting the (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran conformation, just as has been observed in the crystal structures of the Salmonella typhimurium and Sinorhizobium meliloti LsrB-AI-2 complexes.
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===Crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2===
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The structure of LsrB from Yersinia pestis complexed with autoinducer-2.,Kavanaugh JS, Gakhar L, Horswill AR Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1501-5., Epub 2011 Nov 29. PMID:22139152<ref>PMID:22139152</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3t95" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22139152 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22139152}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3t95]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T95 OCA].
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[[Category: Yersinia pestis CO92]]
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[[Category: Gakhar L]]
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==Reference==
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[[Category: Horswill AR]]
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<ref group="xtra">PMID:022139152</ref><references group="xtra"/>
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[[Category: Kavanaugh JS]]
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[[Category: Yersinia pestis]]
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[[Category: Gakhar, L.]]
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[[Category: Horswill, A R.]]
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[[Category: Kavanaugh, J S.]]
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[[Category: Periplasmic binding protein fold]]
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[[Category: Periplasmic space]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2

PDB ID 3t95

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