4e8u

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(New page: '''Unreleased structure''' The entry 4e8u is ON HOLD Authors: Simanshu, Dhirendra K., Patel, Dinshaw J. Description: Crystal structure of Arabidopsis IDN2 XS domain along with a small ...)
Current revision (11:02, 1 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4e8u is ON HOLD
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==Crystal structure of Arabidopsis IDN2 XS domain along with a small segment of adjacent coiled-coil region==
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<StructureSection load='4e8u' size='340' side='right'caption='[[4e8u]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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Authors: Simanshu, Dhirendra K., Patel, Dinshaw J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4e8u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E8U FirstGlance]. <br>
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Description: Crystal structure of Arabidopsis IDN2 XS domain along with a small segment of adjacent coiled-coil region
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.701&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e8u OCA], [https://pdbe.org/4e8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e8u RCSB], [https://www.ebi.ac.uk/pdbsum/4e8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e8u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IDN2_ARATH IDN2_ARATH] Forms a complex with FDM1/IDNL1 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway (PubMed:22570638, PubMed:22592791) and downstream of small interfering RNA (siRNA) formation (PubMed:22810086). Required for de novo DNA methylation, siRNA accumulation and siRNA-mediated maintenance methylation (PubMed:19915591). Required for several post-transcriptional gene silencing pathways (PubMed:20059743). Binds double-stranded RNAs (dsRNAs) with 5'-overhangs through its XS domain (PubMed:19915591, PubMed:20059743). Binds long non-coding RNA (lncRNA) in an AGO4-dependent manner and associates with DRM2, resulting in DNA methylation of RdDM target loci (PubMed:23246435, PubMed:24862207). Mediates the silencing of a subset of MORC6 target loci (PubMed:27171427).<ref>PMID:19915591</ref> <ref>PMID:20059743</ref> <ref>PMID:22570638</ref> <ref>PMID:22592791</ref> <ref>PMID:22810086</ref> <ref>PMID:23246435</ref> <ref>PMID:24862207</ref> <ref>PMID:27171427</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arabidopsis thaliana]]
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[[Category: Large Structures]]
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[[Category: Patel DJ]]
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[[Category: Simanshu DK]]

Current revision

Crystal structure of Arabidopsis IDN2 XS domain along with a small segment of adjacent coiled-coil region

PDB ID 4e8u

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