4e71

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_4e71", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Current revision (14:54, 14 March 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4e71.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of the RHO GTPASE binding domain of Plexin B2==
-
The line below this paragraph, containing "STRUCTURE_4e71", creates the "Structure Box" on the page.
+
<StructureSection load='4e71' size='340' side='right'caption='[[4e71]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4e71]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E71 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
{{STRUCTURE_4e71| PDB=4e71 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e71 OCA], [https://pdbe.org/4e71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e71 RCSB], [https://www.ebi.ac.uk/pdbsum/4e71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e71 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PLXB2_HUMAN PLXB2_HUMAN] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity).
-
===Crystal structure of the RHO GTPASE binding domain of Plexin B2===
+
==See Also==
-
 
+
*[[Plexin 3D structures|Plexin 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
[[4e71]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA].
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Bountra, C.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Edwards, A M.]]
+
[[Category: Bountra C]]
-
[[Category: Guan, X.]]
+
[[Category: Edwards AM]]
-
[[Category: Park, H.]]
+
[[Category: Guan X]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Park H]]
-
[[Category: Tempel, W.]]
+
[[Category: Tempel W]]
-
[[Category: Tong, Y.]]
+
[[Category: Tong Y]]
-
[[Category: Wang, H.]]
+
[[Category: Wang H]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt J]]
-
[[Category: Plexin]]
+
-
[[Category: Rbd]]
+
-
[[Category: Sgc]]
+
-
[[Category: Signaling]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Transmembrane]]
+

Current revision

Crystal structure of the RHO GTPASE binding domain of Plexin B2

PDB ID 4e71

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4e71"
Personal tools