Oligopeptide-binding protein

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<StructureSection load='' size='350' side='right' caption='Oligopeptide-binding protein (grey) complex with peptide bradykinin (cyan) and Cl- ion (green) (PDB entry [[3drg]])' scene='48/488461/Cv/1'>
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== Function ==
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'''Oligopeptide-binding protein''' (Opp) is a component of the
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oligopeptide permease which is an ABC-type transporter system. Opp binds polypeptides up to pentapeptide in length with high affinity. Opp is required for sporulation and competence. Opp carries oligopeptides to the membrane-associated oligopeptide permease<ref>PMID:14618258</ref>.
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'''Oligopeptide-binding protein''' (OBP) is a component of the
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oligopeptide permease which is an ABC-type transporter system. OBP binds polypeptides up to pentapeptide in length with high affinity. OBP is required for sporulation and competence. OBP carries oligopeptides to the membrane-associated oligopeptide permease.
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==3D structures of oligopeptide-binding protein==
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== Structural highlights ==
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The bradykinin peptide is nestled between the 2 domains of Opp<ref>PMID:19300437</ref>. <scene name='48/488461/Cv/6'>Bradykinin peptide binding site</scene>.
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*<scene name='48/488461/Cv/7'>Cl coordination site</scene>. Water molecule is shown as red sphere.
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</StructureSection>
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==3D structures of oligopeptide-binding protein==
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[[1rkm]] – StOBP – ''Salmonella typhimurium''<br />
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[[3fto]] - LlOBP – ''Lactococcus lactis''
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'''Oligopeptide-binding protein complex with polypeptide'''
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See [[ABC transporter]]
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[[1ola]], [[1olc]] – StOBP + tetrapeptide<br />
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== References ==
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[[2olb]], [[1jet]], [[1jeu]], [[1jev]], [[1b1h]], [[1b3f]], [[1b3g]], [[1b3l]], [[1b32]], [[1b40]], [[1b46]], [[1b4z]], [[1b5i]], [[1b5j]], [[1b51]], [[1b52]], [[1b58]], [[1b9j]], [[1b0h]], [[1b05]], [[1qka]], [[1qkb]] - StOBP + tripeptide<br />
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<references/>
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[[2rkm]] - StOBP + dipeptide<br />
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[[Category:Topic Page]]
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[[1b4h]] - StOBP + Lys-DAB-Lys<br />
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[[1b5h]] - StOBP + Lys-DPP-Lys<br />
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[[1b6h]] - StOBP + Lys-NVA-Lys<br />
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[[1b7h]] - StOBP + Lys-NLE-Lys<br />
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[[1b2h]] - StOBP + Lys-ORN-Lys<br />
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[[1b1h]] - StOBP + Lys-HPE-Lys<br />
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[[1b3h]] - StOBP + Lys-ALC-Lys<br />
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[[2z23]] - OBP + tripeptide – ''Yersinia pestis''<br />
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[[3drf]], [[3dri]] - LlOBP + octapeptide<br />
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[[3rya]], [[3ryb]] - LlOBP + nonapeptide<br />
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[[3drg]] - LlOBP + bradykinin<br />
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[[3drh]] - LlOBP + hexapeptide<br />
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[[3drj]] - LlOBP + PTH-related peptide<br />
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[[3drk]] - LlOBP + neuropeptide S
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Current revision

Oligopeptide-binding protein (grey) complex with peptide bradykinin (cyan) and Cl- ion (green) (PDB entry 3drg)

Drag the structure with the mouse to rotate

3D structures of oligopeptide-binding protein

See ABC transporter

References

  1. ↑ Monnet V. Bacterial oligopeptide-binding proteins. Cell Mol Life Sci. 2003 Oct;60(10):2100-14. PMID:14618258 doi:http://dx.doi.org/10.1007/s00018-003-3054-3
  2. ↑ Berntsson RP, Doeven MK, Fusetti F, Duurkens RH, Sengupta D, Marrink SJ, Thunnissen AM, Poolman B, Slotboom DJ. The structural basis for peptide selection by the transport receptor OppA. EMBO J. 2009 Mar 19. PMID:19300437 doi:emboj200965

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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