3tnz

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[[Image:3tnz.png|left|200px]]
 
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==Crystal structure of Mus musculus iodotyrosine deiodinase (IYD) C217A, C239A bound to FMN and mono-iodotyrosine (MIT)==
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The line below this paragraph, containing "STRUCTURE_3tnz", creates the "Structure Box" on the page.
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<StructureSection load='3tnz' size='340' side='right'caption='[[3tnz]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tnz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TNZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IYR:3-IODO-TYROSINE'>IYR</scene></td></tr>
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{{STRUCTURE_3tnz| PDB=3tnz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tnz OCA], [https://pdbe.org/3tnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tnz RCSB], [https://www.ebi.ac.uk/pdbsum/3tnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tnz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IYD1_MOUSE IYD1_MOUSE] Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine (By similarity).
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===Crystal structure of Mus musculus iodotyrosine deiodinase (IYD) C217A, C239A bound to FMN and mono-iodotyrosine (MIT)===
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==See Also==
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*[[Dehalogenase 3D structures|Dehalogenase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22238141 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22238141}}
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==About this Structure==
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[[3tnz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TNZ OCA].
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==Reference==
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<ref group="xtra">PMID:022238141</ref><references group="xtra"/>
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[[Category: Iodotyrosine deiodinase]]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Buss, J M.]]
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[[Category: Buss JM]]
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[[Category: McTamney, P M.]]
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[[Category: McTamney PM]]
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[[Category: Rokita, S E.]]
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[[Category: Rokita SE]]
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[[Category: Dehalogenase]]
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[[Category: Flavoprotein]]
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[[Category: Fmn]]
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[[Category: Iodide salvage]]
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[[Category: Membrane]]
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[[Category: Mit]]
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[[Category: Mono-iodotyrosine]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure of Mus musculus iodotyrosine deiodinase (IYD) C217A, C239A bound to FMN and mono-iodotyrosine (MIT)

PDB ID 3tnz

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OCA

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