4e29

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[[Image:4e29.png|left|200px]]
 
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==Periplasmic domain of the chimeric WzzB chain length regulator protein==
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The line below this paragraph, containing "STRUCTURE_4e29", creates the "Structure Box" on the page.
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<StructureSection load='4e29' size='340' side='right'caption='[[4e29]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4e29]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] and [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E29 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_4e29| PDB=4e29 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e29 OCA], [https://pdbe.org/4e29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e29 RCSB], [https://www.ebi.ac.uk/pdbsum/4e29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e29 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The surface O-antigen polymers of gram-negative bacteria exhibit a modal length distribution that depends on dedicated chain-length regulator periplasmic proteins (Polysaccharide Co-Polymerases, PCPs) anchored in the inner membrane by two transmembrane helices. In an attempt to determine whether structural changes underlie the O-antigen modal length specification we have determined crystal structures of several closely related PCPs, namely two chimeric PCP-1 family members solved at 1.5A and 2.6A and a wild-type PCP-1 from Shigella flexneri solved at 2.8A. The chimeric proteins form circular octamers while the wild type WzzB from Shigella flexneri was found to be an open trimer. We also present the structure of a WzzBFepE mutant, which exhibits severe attenuation in its ability to produce very long O-antigen polymers. Our findings suggest that the differences in the modal length distribution depend primarily on the surface-exposed amino acids in specific regions rather than on the differences in the oligomeric state of the PCP protomers.
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===Periplasmic domain of the chimeric WzzB chain length regulator protein===
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Structural characterization of closely related o-antigen LPS-chain length regulators.,Kalynych S, Yao D, Magee J, Cygler M J Biol Chem. 2012 Mar 21. PMID:22437828<ref>PMID:22437828</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22437828}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 4e29" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22437828 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22437828}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4e29]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri,_salmonella_enterica_subsp._enterica_serovar_typhimurium Shigella flexneri, salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E29 OCA].
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Shigella flexneri]]
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==Reference==
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[[Category: Cygler M]]
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<ref group="xtra">PMID:022437828</ref><references group="xtra"/>
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[[Category: Kalynych S]]
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[[Category: Shigella flexneri, salmonella enterica subsp. enterica serovar typhimurium]]
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[[Category: Magee JD]]
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[[Category: Cygler, M.]]
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[[Category: Yao D]]
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[[Category: Kalynych, S.]]
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[[Category: Magee, J D.]]
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[[Category: Yao, D.]]
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[[Category: Inner membrane]]
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[[Category: Membrane protein]]
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[[Category: Regulation of lps o-antigen chain length]]
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[[Category: Wzz]]
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Current revision

Periplasmic domain of the chimeric WzzB chain length regulator protein

PDB ID 4e29

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