3jz3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3jz3" [edit=sysop:move=sysop])
Current revision (06:22, 27 November 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3jz3.png|left|200px]]
 
-
<!--
+
==Structure of the cytoplasmic segment of histidine kinase QseC==
-
The line below this paragraph, containing "STRUCTURE_3jz3", creates the "Structure Box" on the page.
+
<StructureSection load='3jz3' size='340' side='right'caption='[[3jz3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3jz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JZ3 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_3jz3| PDB=3jz3 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz3 OCA], [https://pdbe.org/3jz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jz3 RCSB], [https://www.ebi.ac.uk/pdbsum/3jz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jz3 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/QSEC_ECOLI QSEC_ECOLI] Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation.<ref>PMID:11929534</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jz3_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jz3 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
QseC is a histidine kinase (HK) receptor involved in quorum sensing, a mechanism by which bacteria respond to fluctuations in cell population. We conducted a structural study of the cytoplasmic domain of QseC (QseC-CD) using X-ray crystallography. The 2.5 A structure of the apo-enzyme revealed that the kinase domain of QseC retains the overall fold of the typical HK kinase domain. The construct that we used is inactive in the autokinase reaction and its inactivity is most likely caused by its atypical dimerization interface, as compared to that observed in the T.maritima HK cytoplasmic domain structure. Restoration of the activity may require that the entire dimerization domain be present in the protein construct. QseC, which plays an important role in bacterial pathogenesis, is a promising drug target and the structure of QseC-CD provides a platform for developing more potent inhibitors of pathogen virulence.
-
===Structure of the cytoplasmic segment of histidine kinase QseC===
+
Structure of the Cytoplasmic Segment of Histidine Kinase Receptor QseC, a Key Player in Bacterial Virulence.,Xie W, Dickson C, Kwiatkowski W, Choe S Protein Pept Lett. 2010 Jul 1. PMID:20594156<ref>PMID:20594156</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20594156}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3jz3" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 20594156 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_20594156}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Escherichia coli K-12]]
-
[[3jz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ3 OCA].
+
[[Category: Large Structures]]
-
 
+
[[Category: Choe S]]
-
==Reference==
+
[[Category: Kwiatkowski W]]
-
<ref group="xtra">PMID:020594156</ref><references group="xtra"/>
+
[[Category: Xie W]]
-
[[Category: Escherichia coli]]
+
-
[[Category: Histidine kinase]]
+
-
[[Category: CSMP, Center for Structures of Membrane Proteins.]]
+
-
[[Category: Choe, S.]]
+
-
[[Category: Kwiatkowski, W.]]
+
-
[[Category: Xie, W.]]
+
-
[[Category: Atp-binding]]
+
-
[[Category: Cell inner membrane]]
+
-
[[Category: Cell membrane]]
+
-
[[Category: Helix-turn-helix]]
+
-
[[Category: Kinase]]
+
-
[[Category: Kinase domain]]
+
-
[[Category: Membrane]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Transferase]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Two-component regulatory system]]
+

Current revision

Structure of the cytoplasmic segment of histidine kinase QseC

PDB ID 3jz3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3jz3"
Personal tools