3j1o

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'''Unreleased structure'''
 
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The entry 3j1o is ON HOLD
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==Cryo-EM map of a yeast minimal preinitiation complex interacting with the Mediator Head module==
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<SX load='3j1o' size='340' side='right' viewer='molstar' caption='[[3j1o]], [[Resolution|resolution]] 16.00&Aring;' scene=''>
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Authors: Asturias, F.J., Imasaki, T., ,, ,, ,, ,, ,, ,
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3j1o]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J1O FirstGlance]. <br>
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Description: Cryo-EM map of a yeast minimal preinitiation complex interacting with the Mediator Head module
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 16&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j1o OCA], [https://pdbe.org/3j1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j1o RCSB], [https://www.ebi.ac.uk/pdbsum/3j1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j1o ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MED17_YEAST MED17_YEAST] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.<ref>PMID:11555651</ref> <ref>PMID:16076843</ref> <ref>PMID:16263706</ref> <ref>PMID:16885025</ref> <ref>PMID:9845373</ref>
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Asturias FJ]]
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[[Category: Imasaki T]]

Current revision

Cryo-EM map of a yeast minimal preinitiation complex interacting with the Mediator Head module

3j1o, resolution 16.00Å

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