4dvi

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[[Image:4dvi.jpg|left|200px]]
 
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==Crystal structure of Tankyrase 1 with IWR2==
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The line below this paragraph, containing "STRUCTURE_4dvi", creates the "Structure Box" on the page.
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<StructureSection load='4dvi' size='340' side='right'caption='[[4dvi]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dvi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DVI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2IW:4-[(3AR,4S,7R,7AS)-1,3-DIOXO-1,3,3A,4,7,7A-HEXAHYDRO-2H-4,7-METHANOISOINDOL-2-YL]-N-(4-METHYLQUINOLIN-8-YL)BENZAMIDE'>2IW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_4dvi| PDB=4dvi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dvi OCA], [https://pdbe.org/4dvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dvi RCSB], [https://www.ebi.ac.uk/pdbsum/4dvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dvi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TNKS1_HUMAN TNKS1_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.<ref>PMID:10988299</ref> <ref>PMID:11739745</ref> <ref>PMID:16076287</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> <ref>PMID:22864114</ref>
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===Crystal structure of Tankyrase 1 with IWR2===
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==See Also==
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22438990 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22438990}}
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==About this Structure==
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[[4dvi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVI OCA].
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==Reference==
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<ref group="xtra">PMID:022438990</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Huang, X.]]
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[[Category: Large Structures]]
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[[Category: Inhibitor]]
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[[Category: Huang X]]
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[[Category: Iwr2]]
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[[Category: Parp]]
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[[Category: Tankyrase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of Tankyrase 1 with IWR2

PDB ID 4dvi

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OCA

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