4d9s

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[[Image:4d9s.jpg|left|200px]]
 
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==Crystal structure of Arabidopsis thaliana UVR8 (UV Resistance locus 8)==
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The line below this paragraph, containing "STRUCTURE_4d9s", creates the "Structure Box" on the page.
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<StructureSection load='4d9s' size='340' side='right'caption='[[4d9s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4d9s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D9S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.701&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9s OCA], [https://pdbe.org/4d9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d9s RCSB], [https://www.ebi.ac.uk/pdbsum/4d9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9s ProSAT]</span></td></tr>
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{{STRUCTURE_4d9s| PDB=4d9s | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of Arabidopsis thaliana UVR8 (UV Resistance locus 8)===
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[https://www.uniprot.org/uniprot/UVR8_ARATH UVR8_ARATH] UV-B specific signaling component that acts as UV-B photoreceptor and plays a key role in establishing UV-protective responses in plants. Upon UV-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, accumulates in the nucleus, interacts with the photomorphogenic repressor COP1 and regulates the expression of the transcription factor HY5 by associating with chromatin (through histone H2B binding) in the HY5 promoter region. UVR8 is involved in controlling aspects of leaf growth and morphogenesis in response to UV-B, is required for normal progression of endocycle and has a regulatory role in stomatal differentiation. Is required for plant circadian clock response to photomorphogenic UV-B light, partly through the transcriptional activation of responsive clock genes. Promotes photosynthetic efficiency at elevated levels of UV-B. Plays a role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway. The two tryptophans, Trp-285 and Trp-233, serve collectively as the UV-B chromophore.<ref>PMID:16330762</ref> <ref>PMID:17720867</ref> <ref>PMID:18055587</ref> <ref>PMID:19165148</ref> <ref>PMID:19402876</ref> <ref>PMID:21041653</ref> <ref>PMID:21395889</ref> <ref>PMID:21454788</ref> <ref>PMID:22447155</ref> <ref>PMID:23161229</ref> <ref>PMID:23012433</ref> <ref>PMID:22988111</ref>
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== References ==
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<references/>
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 22323738 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22323738}}
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==About this Structure==
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[[4d9s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9S OCA].
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==Reference==
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<ref group="xtra">PMID:022323738</ref><references group="xtra"/>
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[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Arvai, A S.]]
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[[Category: Large Structures]]
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[[Category: Christie, J M.]]
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[[Category: Arvai AS]]
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[[Category: Getzoff, E D.]]
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[[Category: Christie JM]]
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[[Category: Hitomi, K.]]
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[[Category: Getzoff ED]]
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[[Category: Pratt, A J.]]
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[[Category: Hitomi K]]
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[[Category: Chromatin-binding protein]]
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[[Category: Pratt AJ]]
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[[Category: Cop1]]
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[[Category: Homodimer]]
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[[Category: Tryptophan chromophore]]
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[[Category: Uv resistance]]
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[[Category: Uv-b photoreceptor]]
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Current revision

Crystal structure of Arabidopsis thaliana UVR8 (UV Resistance locus 8)

PDB ID 4d9s

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