3s3g

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[[Image:3s3g.jpg|left|200px]]
 
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==Crystal Structure of Human Aldose Reductase Complexed with Tolmetin==
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The line below this paragraph, containing "STRUCTURE_3s3g", creates the "Structure Box" on the page.
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<StructureSection load='3s3g' size='340' side='right'caption='[[3s3g]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3s3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S3G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=TLT:TOLMETIN'>TLT</scene></td></tr>
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{{STRUCTURE_3s3g| PDB=3s3g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3g OCA], [https://pdbe.org/3s3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s3g RCSB], [https://www.ebi.ac.uk/pdbsum/3s3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s3g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sulindac (SLD) exhibits both the highest inhibitory activity towards human aldose reductase (AR) among popular non-steroidal anti-inflammatory drugs and clear beneficial clinical effects on Type 2 diabetes. However, the molecular basis for these properties is unclear. Here, we report that SLD and its pharmacologically active/inactive metabolites, SLD sulfide and SLD sulfone, are equally effective as un-competitive inhibitors of AR in vitro. Crystallographic analysis reveals that pi-pi stacking favored by the distinct scaffold of SLDs is pivotal to their high AR inhibitory activities. These results also suggest that SLD sulfone could be a potent lead compound for AR inhibition in vivo.
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===Crystal Structure of Human Aldose Reductase Complexed with Tolmetin===
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The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.,Zheng X, Zhang L, Zhai J, Chen Y, Luo H, Hu X FEBS Lett. 2012 Jan 2;586(1):55-9. Epub 2011 Dec 8. PMID:22155003<ref>PMID:22155003</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3s3g" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22155003}}, adds the Publication Abstract to the page
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22155003 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22155003}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3s3g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3G OCA].
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==Reference==
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<ref group="xtra">PMID:022155003</ref><references group="xtra"/>
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[[Category: Aldehyde reductase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, J.]]
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[[Category: Large Structures]]
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[[Category: Hu, X.]]
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[[Category: Chen J]]
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[[Category: Luo, H.]]
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[[Category: Hu X]]
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[[Category: Zheng, X.]]
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[[Category: Luo H]]
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[[Category: Human aldose reductase]]
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[[Category: Zheng X]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal Structure of Human Aldose Reductase Complexed with Tolmetin

PDB ID 3s3g

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