3v30

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[[Image:3v30.jpg|left|200px]]
 
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==Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human RFXANK==
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The line below this paragraph, containing "STRUCTURE_3v30", creates the "Structure Box" on the page.
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<StructureSection load='3v30' size='340' side='right'caption='[[3v30]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3v30]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V30 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v30 OCA], [https://pdbe.org/3v30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v30 RCSB], [https://www.ebi.ac.uk/pdbsum/3v30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v30 ProSAT]</span></td></tr>
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{{STRUCTURE_3v30| PDB=3v30 | SCENE= }}
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</table>
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== Disease ==
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===Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human RFXANK===
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[https://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9806546</ref> <ref>PMID:10072068</ref> <ref>PMID:10725724</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN] Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
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==About this Structure==
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== References ==
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[[3v30]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V30 OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bian, C B.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bian CB]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Bountra C]]
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[[Category: Kania, J.]]
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[[Category: Edwards AM]]
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[[Category: Lam, R.]]
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[[Category: Kania J]]
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[[Category: Min, J.]]
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[[Category: Lam R]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Min J]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Xu, C.]]
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[[Category: Xu C]]
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[[Category: Ank repeat]]
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[[Category: Protein binding]]
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[[Category: Rfx5]]
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[[Category: Rfxank]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human RFXANK

PDB ID 3v30

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