User:Jamie Abbott/Sandbox2

== Histidyl-tRNA Synthetase ==

Histidyl tRNA Synthetase (HisRS) is a 94kD homodimer that belongs to the Class II of aminoacyl-tRNA synthetases (aaRS). Class II enzymes have a <scene name='User:Jamie_Abbott/Sandbox2/Catalytic_domain/1'>catalytic domain</scene> composed of anti-parallel β-sheets and α-helices (residues 1-325).

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== Function and Catalysis ==

Class II aminoacyl-tRNA synthetases aminoacylate the 3'OH of their cognate tRNAs.

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== Mechanism ==

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<Structure load='1KMM' name='HisRS' size='500' frame='true' align='left' caption='Histidyl-tRNA Synthetase Complexed with Histidyl-Adenylate'>

<scene name='User:Jamie_Abbott/Sandbox2/Hisrsdimer/2'>Dimer</scene>

<scene name='User:Jamie_Abbott/Sandbox2/Hisrsdimer_to_monomer/2'>Monomer</scene>

<scene name='User:Jamie_Abbott/Sandbox2/Motif_i/3'>Motif I</scene>

<scene name='User:Jamie_Abbott/Sandbox2/Motif_ii/2'>Motif II</scene>

<scene name='User:Jamie_Abbott/Sandbox2/Motif_iii/4'>Motif III</scene>

<scene name='User:Jamie_Abbott/Sandbox2/Hisa_loop/1'>HisA Loop</scene>

== References ==

<references/>