3pum

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[[Image:3pum.png|left|200px]]
 
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==Crystal structure of P domain dimer of Norovirus VA207==
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The line below this paragraph, containing "STRUCTURE_3pum", creates the "Structure Box" on the page.
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<StructureSection load='3pum' size='340' side='right'caption='[[3pum]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pum]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_calicivirus_NLV/VA97207/1997 Human calicivirus NLV/VA97207/1997]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PUM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.252&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pum OCA], [https://pdbe.org/3pum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pum RCSB], [https://www.ebi.ac.uk/pdbsum/3pum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pum ProSAT]</span></td></tr>
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{{STRUCTURE_3pum| PDB=3pum | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q91H09_9CALI Q91H09_9CALI]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Noroviruses, an important cause of acute gastroenteritis in humans, recognize the histo-blood group antigens (HBGAs) as host susceptible factors in a strain-specific manner. The crystal structures of the HBGA-binding interfaces of two A/B/H-binding noroviruses, the prototype Norwalk virus (GI.1) and a predominant GII.4 strain (VA387), have been elucidated. In this study we determined the crystal structures of the P domain protein of the first Lewis-binding norovirus (VA207, GII.9) that has a distinct binding property from those of Norwalk virus and VA387. Co-crystallization of the VA207 P dimer with Le(y) or sialyl Le(x) tetrasaccharides showed that VA207 interacts with these antigens through a common site found on the VA387 P protein which is highly conserved among most GII noroviruses. However, the HBGA-binding site of VA207 targeted at the Lewis antigens through the alpha-1, 3 fucose (the Lewis epitope) as major and the beta-N-acetyl glucosamine of the precursor as minor interacting sites. This completely differs from the binding mode of VA387 and Norwalk virus that target at the secretor epitopes. Binding pocket of VA207 is formed by seven amino acids, of which five residues build up the core structure that is essential for the basic binding function, while the other two are involved in strain-specificity. Our results elucidate for the first time the genetic and structural basis of strain-specificity by a direct comparison of two genetically related noroviruses in their interaction with different HBGAs. The results provide insight into the complex interaction between the diverse noroviruses and the polymorphic HBGAs and highlight the role of human HBGA as a critical factor in norovirus evolution.
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===Crystal structure of P domain dimer of Norovirus VA207===
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Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens.,Chen Y, Tan M, Xia M, Hao N, Zhang XC, Huang P, Jiang X, Li X, Rao Z PLoS Pathog. 2011 Jul;7(7):e1002152. Epub 2011 Jul 21. PMID:21811409<ref>PMID:21811409</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21811409}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3pum" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21811409 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21811409}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human calicivirus NLV/VA97207/1997]]
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[[3pum]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_isolates Norovirus isolates]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUM OCA].
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[[Category: Large Structures]]
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[[Category: Chen Y]]
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==Reference==
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[[Category: Hao N]]
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<ref group="xtra">PMID:021811409</ref><references group="xtra"/>
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[[Category: Huang P]]
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[[Category: Norovirus isolates]]
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[[Category: Jiang X]]
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[[Category: Chen, Y.]]
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[[Category: Li X]]
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[[Category: Hao, N.]]
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[[Category: Rao Z]]
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[[Category: Huang, P.]]
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[[Category: Tan M]]
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[[Category: Jiang, X.]]
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[[Category: Xia M]]
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[[Category: Li, X.]]
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[[Category: Zhang XC]]
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[[Category: Rao, Z.]]
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[[Category: Tan, M.]]
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[[Category: Xia, M.]]
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[[Category: Zhang, X C.]]
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[[Category: Capsid]]
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[[Category: Carbohydrate/sugar binding]]
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[[Category: Greek key]]
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[[Category: Mixed alpha/beta structure]]
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[[Category: Receptor binding]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of P domain dimer of Norovirus VA207

PDB ID 3pum

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