2xqx

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[[Image:2xqx.png|left|200px]]
 
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==Structure of the family 32 carbohydrate-binding module from Streptococcus pneumoniae EndoD==
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The line below this paragraph, containing "STRUCTURE_2xqx", creates the "Structure Box" on the page.
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<StructureSection load='2xqx' size='340' side='right'caption='[[2xqx]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xqx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2xqx| PDB=2xqx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqx OCA], [https://pdbe.org/2xqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqx RCSB], [https://www.ebi.ac.uk/pdbsum/2xqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0H2UNT5_STRPN A0A0H2UNT5_STRPN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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EndoD is an architecturally complex endo-beta-1,4-N-acetylglucosamidase from Streptococcus pneumoniae that cleaves the chitobiose core of N-linked glycans and contributes to pneumococcal virulence. Although the glycoside hydrolase family 85 catalytic module has been structurally and functionally characterized, nothing is known about the ancillary modules and how they contribute to the overall function of the enzyme. Presented here is the 2.0 A resolution structure of a family 32 carbohydrate-binding module of EndoD, SpCBM32, solved by single-wavelength anomalous dispersion. The putative binding site of this protein is a charge-neutral relatively flat region on the protein surface that contains one prominently exposed tryptophan residue that extends into the solvent. These topographical features are discussed in the biological context of EndoD activity and a hypothesis is made about the complex structure of its potential carbohydrate ligand.
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===Structure of the family 32 carbohydrate-binding module from Streptococcus pneumoniae EndoD===
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Structural analysis of a putative family 32 carbohydrate-binding module from the Streptococcus pneumoniae enzyme EndoD.,Abbott DW, Boraston A Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt 4):429-33., Epub 2011 Mar 24. PMID:21505233<ref>PMID:21505233</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2xqx" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21505233 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21505233}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2xqx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQX OCA].
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[[Category: Streptococcus pneumoniae TIGR4]]
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[[Category: Abbott DW]]
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==Reference==
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[[Category: Boraston AB]]
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<ref group="xtra">PMID:021505233</ref><references group="xtra"/>
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[[Category: Streptococcus pneumoniae]]
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[[Category: Abbott, D W.]]
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[[Category: Boraston, A B.]]
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[[Category: Beta-sandwhich]]
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[[Category: Carbohydrate binding]]
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[[Category: Sugar binding protein]]
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Current revision

Structure of the family 32 carbohydrate-binding module from Streptococcus pneumoniae EndoD

PDB ID 2xqx

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