3mcb

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[[Image:3mcb.png|left|200px]]
 
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==Crystal structure of NAC domains of human nascent polypeptide-associated complex (NAC)==
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The line below this paragraph, containing "STRUCTURE_3mcb", creates the "Structure Box" on the page.
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<StructureSection load='3mcb' size='340' side='right'caption='[[3mcb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mcb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MCB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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{{STRUCTURE_3mcb| PDB=3mcb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mcb OCA], [https://pdbe.org/3mcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mcb RCSB], [https://www.ebi.ac.uk/pdbsum/3mcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mcb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NACA_HUMAN NACA_HUMAN] Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.<ref>PMID:9877153</ref> <ref>PMID:10982809</ref> <ref>PMID:15784678</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mc/3mcb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mcb ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of NAC domains of human nascent polypeptide-associated complex (NAC)===
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==See Also==
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*[[NAC transcription factor|NAC transcription factor]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21203952 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21203952}}
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==About this Structure==
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[[3mcb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCB OCA].
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==Reference==
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<ref group="xtra">PMID:021203952</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, X M.]]
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[[Category: Large Structures]]
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[[Category: Rao, Z.]]
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[[Category: Li XM]]
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[[Category: Wang, L.]]
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[[Category: Rao Z]]
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[[Category: Wang, L F.]]
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[[Category: Wang L]]
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[[Category: Zhang, W C.]]
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[[Category: Wang LF]]
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[[Category: Zhang, X J.C.]]
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[[Category: Zhang WC]]
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[[Category: Beta-barrel like structure]]
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[[Category: Zhang XJC]]
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[[Category: Chaperone]]
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[[Category: Heterodimer]]
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[[Category: Nac]]
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Current revision

Crystal structure of NAC domains of human nascent polypeptide-associated complex (NAC)

PDB ID 3mcb

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OCA

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