3tku

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[[Image:3tku.png|left|200px]]
 
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==MRCK beta in complex with fasudil==
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The line below this paragraph, containing "STRUCTURE_3tku", creates the "Structure Box" on the page.
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<StructureSection load='3tku' size='340' side='right'caption='[[3tku]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tku]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TKU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M77:5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE'>M77</scene></td></tr>
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{{STRUCTURE_3tku| PDB=3tku | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tku OCA], [https://pdbe.org/3tku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tku RCSB], [https://www.ebi.ac.uk/pdbsum/3tku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tku ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MRCKB_HUMAN MRCKB_HUMAN] Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.<ref>PMID:18854160</ref> <ref>PMID:21457715</ref> <ref>PMID:21949762</ref>
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===MRCK beta in complex with fasudil===
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21949762 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21949762}}
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==About this Structure==
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[[3tku]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TKU OCA].
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==Reference==
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<ref group="xtra">PMID:021949762</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Crighton, D.]]
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[[Category: Crighton D]]
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[[Category: Heikkila, T J.]]
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[[Category: Heikkila TJ]]
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[[Category: Olson, M F.]]
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[[Category: Olson MF]]
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[[Category: Schroder, E.]]
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[[Category: Schroder E]]
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[[Category: Turnbull, A.]]
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[[Category: Turnbull A]]
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[[Category: Wheatley, E.]]
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[[Category: Wheatley E]]
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[[Category: Cd binding protein kinase beta]]
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[[Category: Fasudil]]
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[[Category: Mrck]]
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[[Category: Mrck beta]]
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[[Category: Protein kinase]]
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[[Category: Serine threonine kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

MRCK beta in complex with fasudil

PDB ID 3tku

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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