3uv4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:09, 14 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3uv4.png|left|200px]]
 
-
<!--
+
==Crystal Structure of the second bromodomain of human Transcription initiation factor TFIID subunit 1 (TAF1)==
-
The line below this paragraph, containing "STRUCTURE_3uv4", creates the "Structure Box" on the page.
+
<StructureSection load='3uv4' size='340' side='right'caption='[[3uv4]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3uv4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UV4 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
{{STRUCTURE_3uv4| PDB=3uv4 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv4 OCA], [https://pdbe.org/3uv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uv4 RCSB], [https://www.ebi.ac.uk/pdbsum/3uv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uv4 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/TAF1_HUMAN TAF1_HUMAN] Defects in TAF1 are the cause of dystonia type 3 (DYT3) [MIM:[https://omim.org/entry/314250 314250]; also called X-linked dystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. Its prevalence is high in the Philippines. DYT3 has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.<ref>PMID:12928496</ref> <ref>PMID:17273961</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TAF1_HUMAN TAF1_HUMAN] Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.<ref>PMID:2038334</ref> <ref>PMID:8450888</ref> <ref>PMID:8625415</ref> <ref>PMID:9660973</ref> <ref>PMID:9858607</ref> <ref>PMID:11278496</ref> <ref>PMID:15053879</ref>
-
===Crystal Structure of the second bromodomain of human Transcription initiation factor TFIID subunit 1 (TAF1)===
+
==See Also==
-
 
+
*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_22464331}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 22464331 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_22464331}}
+
-
 
+
-
==About this Structure==
+
-
[[3uv4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV4 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022464331</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Non-specific serine/threonine protein kinase]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra C]]
-
[[Category: Delf, F von.]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M.]]
+
[[Category: Filippakopoulos P]]
-
[[Category: Filippakopoulos, P.]]
+
[[Category: Keates T]]
-
[[Category: Keates, T.]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S.]]
+
[[Category: Picaud S]]
-
[[Category: Picaud, S.]]
+
[[Category: Ugochukwu E]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Weigelt J]]
-
[[Category: Ugochukwu, E.]]
+
[[Category: Von Delft F]]
-
[[Category: Weigelt, J.]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Transcription]]
+

Current revision

Crystal Structure of the second bromodomain of human Transcription initiation factor TFIID subunit 1 (TAF1)

PDB ID 3uv4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3uv4"
Personal tools