4eeq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of E. faecalis DNA ligase with inhibitor== | |
| + | <StructureSection load='4eeq' size='340' side='right'caption='[[4eeq]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4eeq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EEQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0OX:4-AMINO-2-(CYCLOPENTYLOXY)PYRIMIDINE-5-CARBOXAMIDE'>0OX</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eeq OCA], [https://pdbe.org/4eeq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eeq RCSB], [https://www.ebi.ac.uk/pdbsum/4eeq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eeq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[DNA ligase 3D structures|DNA ligase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Enterococcus faecalis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Charifson P]] | ||
| + | [[Category: Wang T]] | ||
| + | [[Category: Wei Y]] | ||
Current revision
Crystal structure of E. faecalis DNA ligase with inhibitor
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