4ehq

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m (Protected "4ehq" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 4ehq is ON HOLD
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==Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+/Calmodulin Displays a Unique Binding Mode==
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<StructureSection load='4ehq' size='340' side='right'caption='[[4ehq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ehq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9005&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GBL:GAMMA-BUTYROLACTONE'>GBL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ehq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehq OCA], [https://pdbe.org/4ehq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ehq RCSB], [https://www.ebi.ac.uk/pdbsum/4ehq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_RAT CALM1_RAT] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.[UniProtKB:P62158]
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Authors: Liu, Y., Zheng, X., Mueller, G.A., Sobhany, H, DeRose, E.F., Zhang, Y., London, R.E., Birnbaumer, L.
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==See Also==
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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Description: Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+/Calmodulin Displays a Unique Binding Mode
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Birnbaumer L]]
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[[Category: DeRose EF]]
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[[Category: Liu Y]]
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[[Category: London RE]]
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[[Category: Mueller GA]]
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[[Category: Sobhany M]]
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[[Category: Zhang Y]]
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[[Category: Zheng X]]

Current revision

Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+/Calmodulin Displays a Unique Binding Mode

PDB ID 4ehq

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