2rrs

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[[Image:2rrs.jpg|left|200px]]
 
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==NMR Structure of LC4 transmembrane segment of CCR5==
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The line below this paragraph, containing "STRUCTURE_2rrs", creates the "Structure Box" on the page.
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<StructureSection load='2rrs' size='340' side='right'caption='[[2rrs]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rrs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rrs OCA], [https://pdbe.org/2rrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rrs RCSB], [https://www.ebi.ac.uk/pdbsum/2rrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rrs ProSAT]</span></td></tr>
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{{STRUCTURE_2rrs| PDB=2rrs | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[https://omim.org/entry/612522 612522]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref> <ref>PMID:8663314</ref> <ref>PMID:8699119</ref> <ref>PMID:8649511</ref> <ref>PMID:8649512</ref> <ref>PMID:11323418</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CC-chemokine receptor 5 (CCR5) is a specific co-receptor allowing the entry of human immunodeficiency virus type 1 (HIV-1). The LC4 region in CCR5 is required for HIV-1 entry into the cells. In this study, the solution structure of LC4 in SDS micelles was elucidated by using standard 1H two-dimensional NMR spectroscopy, circular dichroism, and fluorescence quenching. The LC4 structure adopts two helical structures, whereas the C-terminal part remains unstructured. The positions in which LC4 binds to the HIV-1 inhibitory peptide LC5 were determined by docking calculations in addition to NMR data. The poses showed the importance of the hydrophobic interface of the assembled structures. The solution structure of LC4 elucidated in the present work provides a structural basis for further studies on the HIV-1 inhibitory function of the LC4 region.
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===NMR Structure of LC4 transmembrane segment of CCR5===
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Solution structure of LC4 transmembrane segment of CCR5.,Miyamoto K, Togiya K PLoS One. 2011;6(5):e20452. Epub 2011 May 27. PMID:21647380<ref>PMID:21647380</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21647380}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2rrs" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21647380 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21647380}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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[[2rrs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRS OCA].
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[[Category: Large Structures]]
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[[Category: Miyamoto K]]
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==Reference==
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<ref group="xtra">PMID:021647380</ref><references group="xtra"/>
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[[Category: Miyamoto, K.]]
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[[Category: Ccr5]]
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[[Category: Gpcr]]
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[[Category: Hiv]]
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[[Category: Lc4]]
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[[Category: Signaling protein]]
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[[Category: Transmembrane protein]]
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Current revision

NMR Structure of LC4 transmembrane segment of CCR5

PDB ID 2rrs

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