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3r8q

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[[Image:3r8q.jpg|left|200px]]
 
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==Structure of Fibronectin domain 12-14==
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The line below this paragraph, containing "STRUCTURE_3r8q", creates the "Structure Box" on the page.
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<StructureSection load='3r8q' size='340' side='right'caption='[[3r8q]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3r8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R8Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r8q OCA], [https://pdbe.org/3r8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r8q RCSB], [https://www.ebi.ac.uk/pdbsum/3r8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r8q ProSAT]</span></td></tr>
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{{STRUCTURE_3r8q| PDB=3r8q | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[https://omim.org/entry/601894 601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>
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===Structure of Fibronectin domain 12-14===
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==See Also==
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*[[Fibronectin 3D structures|Fibronectin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3r8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R8Q OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Agnew, C.]]
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[[Category: Large Structures]]
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[[Category: Brady, R L.]]
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[[Category: Agnew C]]
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[[Category: Zaccai, N R.]]
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[[Category: Brady RL]]
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[[Category: Cell adhesion]]
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[[Category: Zaccai NR]]
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[[Category: Fibronectin]]
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[[Category: Fniii]]
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[[Category: Heparin]]
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[[Category: Heparin binding]]
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Current revision

Structure of Fibronectin domain 12-14

PDB ID 3r8q

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