3qjn

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[[Image:3qjn.png|left|200px]]
 
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==Structural flexibility of Shank PDZ domain is important for its binding to different ligands==
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The line below this paragraph, containing "STRUCTURE_3qjn", creates the "Structure Box" on the page.
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<StructureSection load='3qjn' size='340' side='right'caption='[[3qjn]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qjn]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QJN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [https://pdbe.org/3qjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [https://www.ebi.ac.uk/pdbsum/3qjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qjn ProSAT]</span></td></tr>
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{{STRUCTURE_3qjn| PDB=3qjn | SCENE= }}
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</table>
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== Function ==
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===Structural flexibility of Shank PDZ domain is important for its binding to different ligands===
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[https://www.uniprot.org/uniprot/SHAN1_RAT SHAN1_RAT] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.<ref>PMID:11498055</ref> <ref>PMID:18287537</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 21376703 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21376703}}
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==About this Structure==
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[[3qjn]] is a 16 chain structure of [[Shank protein]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA].
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==See Also==
==See Also==
*[[Shank protein|Shank protein]]
*[[Shank protein|Shank protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021376703</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Eom, S H.]]
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[[Category: Eom SH]]
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[[Category: Kim, H J.]]
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[[Category: Kim HJ]]
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[[Category: Lee, J H.]]
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[[Category: Lee JH]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: Park, S J.]]
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[[Category: Park SJ]]
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[[Category: Beta-pix]]
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[[Category: Pdz domain]]
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[[Category: Protein binding]]
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[[Category: Protein-protein interaction]]
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Current revision

Structural flexibility of Shank PDZ domain is important for its binding to different ligands

PDB ID 3qjn

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