2ler

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[[Image:2ler.png|left|200px]]
 
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==Conotoxin pc16a==
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The line below this paragraph, containing "STRUCTURE_2ler", creates the "Structure Box" on the page.
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<StructureSection load='2ler' size='340' side='right'caption='[[2ler]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ler]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_pictus Conus pictus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LER FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ler FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ler OCA], [https://pdbe.org/2ler PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ler RCSB], [https://www.ebi.ac.uk/pdbsum/2ler PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ler ProSAT]</span></td></tr>
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{{STRUCTURE_2ler| PDB=2ler | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A novel conotoxin, pc16a, was isolated from the venom of Conus pictus. This is the first peptide characterized from this South-African cone snail and it has only 11 amino acid residues, SCSCKRNFLCC*, with the rare cysteine framework XVI and a monoisotopic mass of 1257.6Da. Two peptides were synthesized with two possible conformations: globular (pc16a_1) and ribbon (pc16a_2). pc16a_1 co-eluted with the native peptide, which indicates a disulfide connectivity I-III, II-IV. The structure of pc16a_1 was determined by NMR. Both synthetic peptides were used to elucidate the biological activity. Bioassays were performed on crickets, ghost shrimps, larvae of the mealworm beetle and mice, but no effect was seen. Using two-electrode voltage clamp, a range of voltage-gated ion channels (Na(v) and K(v)) and nicotinic acetylcholine receptors were screened, but again no activity was found. Hence, the specific target of pc16a still remains to be discovered.
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===Conotoxin pc16a===
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Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity.,Van Der Haegen A, Peigneur S, Dyubankova N, Moller C, Mari F, Diego-Garcia E, Naude R, Lescrinier E, Herdewijn P, Tytgat J Peptides. 2012 Mar;34(1):106-13. Epub 2011 Nov 3. PMID:22079220<ref>PMID:22079220</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22079220}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2ler" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22079220 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22079220}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Conus pictus]]
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[[2ler]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LER OCA].
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[[Category: Large Structures]]
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[[Category: Dyubankova N]]
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==Reference==
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[[Category: Lescrinier E]]
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<ref group="xtra">PMID:022079220</ref><references group="xtra"/>
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[[Category: Peigneur S]]
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[[Category: Dyubankova, N.]]
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[[Category: Tytgat J]]
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[[Category: Haegen, A Van Der.]]
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[[Category: Van Der Haegen A]]
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[[Category: Lescrinier, E.]]
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[[Category: Peigneur, S.]]
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[[Category: Tytgat, J.]]
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[[Category: Toxin]]
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Current revision

Conotoxin pc16a

PDB ID 2ler

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OCA

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