4dep

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[[Image:4dep.png|left|200px]]
 
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==Structure of the IL-1b signaling complex==
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The line below this paragraph, containing "STRUCTURE_4dep", creates the "Structure Box" on the page.
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<StructureSection load='4dep' size='340' side='right'caption='[[4dep]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dep]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DEP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_4dep| PDB=4dep | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dep OCA], [https://pdbe.org/4dep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dep RCSB], [https://www.ebi.ac.uk/pdbsum/4dep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dep ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity. They exert proinflammatory effects by binding a primary receptor that recruits a receptor accessory protein to form a signaling-competent heterotrimeric complex. Here we present the crystal structure of IL-1beta bound to its primary receptor IL-1RI and its receptor accessory protein IL-1RAcP, providing insight into how IL-1-type cytokines initiate signaling and revealing an evolutionary relationship with the fibroblast growth factor receptor family.
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===Structure of the IL-1b signaling complex===
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Structure of the activating IL-1 receptor signaling complex.,Thomas C, Bazan JF, Garcia KC Nat Struct Mol Biol. 2012 Mar 18;19(4):455-7. doi: 10.1038/nsmb.2260. PMID:22426547<ref>PMID:22426547</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4dep" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22426547}}, adds the Publication Abstract to the page
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22426547 is the PubMed ID number.
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_22426547}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4dep]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DEP OCA].
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==Reference==
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<ref group="xtra">PMID:022426547</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Garcia, K C.]]
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[[Category: Large Structures]]
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[[Category: Thomas, C.]]
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[[Category: Garcia KC]]
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[[Category: B-trefoil]]
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[[Category: Thomas C]]
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[[Category: Extracellular]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin]]
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Current revision

Structure of the IL-1b signaling complex

PDB ID 4dep

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