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2k8m

From Proteopedia

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[[Image:2k8m.png|left|200px]]
 
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==S100A13-C2A binary complex structure==
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The line below this paragraph, containing "STRUCTURE_2k8m", creates the "Structure Box" on the page.
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<StructureSection load='2k8m' size='340' side='right'caption='[[2k8m]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k8m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K8M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8m OCA], [https://pdbe.org/2k8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k8m RCSB], [https://www.ebi.ac.uk/pdbsum/2k8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k8m ProSAT]</span></td></tr>
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{{STRUCTURE_2k8m| PDB=2k8m | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/2k8m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k8m ConSurf].
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<div style="clear:both"></div>
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===S100A13-C2A binary complex structure===
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==See Also==
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_19284995}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 19284995 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19284995}}
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==About this Structure==
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[[2k8m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8M OCA].
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==Reference==
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<ref group="xtra">PMID:019284995</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kumar, S M.]]
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[[Category: Large Structures]]
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[[Category: Mohan, S K.]]
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[[Category: Kumar SM]]
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[[Category: Rani, S G.]]
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[[Category: Mohan SK]]
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[[Category: Yu, C.]]
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[[Category: Rani SG]]
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[[Category: C2a]]
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[[Category: Yu C]]
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[[Category: Protein transport]]
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[[Category: Protein-protein complex]]
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[[Category: S100a13]]
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Current revision

S100A13-C2A binary complex structure

PDB ID 2k8m

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OCA

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