4e6s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the SCAN domain from mouse Zfp206== | |
| - | + | <StructureSection load='4e6s' size='340' side='right'caption='[[4e6s]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4e6s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E6S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e6s OCA], [https://pdbe.org/4e6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e6s RCSB], [https://www.ebi.ac.uk/pdbsum/4e6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e6s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZSC10_MOUSE ZSC10_MOUSE] Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4.<ref>PMID:16971461</ref> <ref>PMID:17628018</ref> <ref>PMID:19740739</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Baburajendran N]] | ||
| + | [[Category: Choo SH]] | ||
| + | [[Category: Kolatkar PR]] | ||
| + | [[Category: Liang Y]] | ||
| + | [[Category: Palasingam P]] | ||
| + | [[Category: Rossbach M]] | ||
Current revision
Crystal structure of the SCAN domain from mouse Zfp206
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